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Mechanism for Temporal Encoding in Fear Conditioning

Delay Lines in Perirhinal Cortex and Lateral Amygdala
  • Billie Faulkner
  • Kinh H. Tieu
  • Thomas H. Brown

Abstract

Our neurobiological studies of the lateral amygdala (LA) and perirhinal cortex (PR) suggest a novel and testable hypothesis regarding encoding the time interval between the conditioned stimulus (CS) and unconditioned stimulus (US) in fear conditioning. In such conditioning, the interval between the onset of the CS and the onset of the US can be several seconds or longer. Here we outline our working hypothesis in qualitative terms, showing how the functional anatomy and neurophysiology furnish a platform for encoding the CS-US interval by mapping time onto space and then relying upon a conventional Hebbian learning rule in which the modifications require temporal contiguity of pre- and postsynaptic activity.

Keywords

Conditioned Stimulus Unconditioned Stimulus Fear Conditioning Delay Line Perirhinal Cortex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Billie Faulkner
    • 1
  • Kinh H. Tieu
    • 2
  • Thomas H. Brown
    • 2
  1. 1.Interdepartmental Neuroscience ProgramUSA
  2. 2.Departments of Psychology and Cellular and Molecular PhysiologyYale UniversityNew HavenUSA

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