Memory and Epileptogenesis in Complex Biological and Simulated Systems
Oscillations of neural activity may bind widespread cortical areas into a neural representation that encodes disparate aspects of an event. In order to test this theory we have turned to data collected from complex partial epilepsy (CPE) patients with chronically implanted depth electrodes. Data from regions critical to word and face information processing was analyzed using spectral coherence measurements. Similar analyses of intracranial EEG (iEEG) during seizure episodes display HippoCampal Formation (HCF)—NeoCortical (NC) spectral coherence patterns that are characteristic of specific seizure stages (Klopp et al. 1996). We are now building a computational memory model to examine whether spatio-temporal patterns of human iEEG spectral coherence emerge in a computer simulation of HCF cellular distribution, membrane physiology and synaptic connectivity. Once the model is reasonably scaled it will be used as a tool to explore neural parameters that are critical to memory formation and epileptogenesis.
KeywordsTemporal Lobe Epilepsy Declarative Memory Retrograde Amnesia Transient Global Amnesia Dentate Granule Cell
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- Bower I & Beeman D: The Book of Genesis. Springer-Verlag New York, Inc. 1995.Google Scholar
- Goddard GV & Douglas RM: Does the engram of kindling model the engram of normal long term memory? The Canadian Journal of Neurological Sciences, pp 385–394, 1975.Google Scholar
- Halgren E, et al: Memory dysfunction in epilepsy patients as a derangement of normal physiology. Advance in Neurology 55: 385–410, 1991.Google Scholar
- Klopp J, Nenov V, Simon S, Jones C: One-dimensional strobomaps and coherence maps characterize human depth EEG during seizure activity. Complex Systems Conference Proceedings, pp 34–44, June 1996.Google Scholar
- Mcnamara J: Cellular and molecular basis of epilepsy, The Journal of Neuroscience 14(6): 3413–3425, 1994.Google Scholar
- Rolls E: Functions of neural networks in the hippocampus and neocortex in memory. Neural Models of Plasticity: Experimental and Theoretical Approaches, eds. J.H. Byrne & W.O. Berry (Academic Press, New York) pp240–65, 1989.Google Scholar
- Squire LR: Memory and Brain. Oxford University Press, New York, 1987.Google Scholar