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Integrate-and-Fire Neurons Matched to Physiological F-I Curves Yield High Input Sensitivity and Wide Dynamic Range

  • Todd W. Troyer
  • Kenneth D. Miller

Abstract

Simple integrate-and-fire neurons that accurately reproduce in vitro data from cortical regular spiking cells can display surprisingly sophisticated behavior. To reproduce in vitro f-I plots, voltage after spikes was reset to 5 mV below threshold, and simple spike rate adaptation was added. Small reset results in input sensitivity (high gain) on short time scales; adaptation leads to wide dynamic range over longer time scales. The model displays physiological ISI variability using either delta function or temporally realistic synaptic conductances. Cross correlation between pre- and post-synaptic spikes suggests that cortical neurons may be capable of transmitting information on the millisecond time scale.

Keywords

Firing Rate Spike Train Synaptic Input Steady State Regime Millisecond Time Scale 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Todd W. Troyer
    • 1
  • Kenneth D. Miller
    • 1
  1. 1.Keck Center for Integrative NeuroscienceUniversity of CaliforniaSan FranciscoUSA

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