Abstract
The effects of scopolamine on human memory function are simulated in a network model of the hippocampal formation, incorporating simplified simulations of neurons and synaptic connections. In this model, the dentate gyrus, CAI and CA3 maintain sparse representations of list items and their associated context allowing simulation of recognition and free recall. Blockade of cholinergic effects within this computational representation models the effects of scopolamine. This blockade of cholinergie effects impairs the encoding of new input patterns (as measured by delayed free recall), but not retrieval of previously learned patterns. Additionally, this cholinergic blockade has no significant effect on recognition tasks. The model also accomodates qualitative aspects of both the List Strength Effect and the List Length Effect.
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Wyble, B.P., Hasselmo, M.E. (1997). A Model of the Effects of Scopolamine on Human Memory Performance. In: Bower, J.M. (eds) Computational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9800-5_138
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DOI: https://doi.org/10.1007/978-1-4757-9800-5_138
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