Comparative Serology

  • Jessica H. Lewis


A number of investigators have suggested a relationship between the evolutionary advancement of a vertebrate and the concentration and complexity of its serum proteins. This study measured total proteins and protein electrophoretic patterns in plasmas for 50 animal species representing the six major vertebrate classes. Paper electrophoresis employing sodium barbital buffer at pH 8.6 and ionic strength 0.05 was done on all the animals except the hedgehogs. Gel electrophoresis (Panagel) and immunoelectrophoresis (IEP) were also done on many of the animal plasmas and sera. Antisera to some of the animal plasmas were prepared in rabbits and used for the IEPs and for cross-immunoreactivity tests in agar gel.


Human Platelet Fibrin Degradation Product Fibrin Monomer Animal Plasma Mammalian Plasma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Allington, M. J., 1967, Fibrinogen and fibrin degradation products and the clumping of staphylococci by serum, Br. J. Haematol. 13: 550.PubMedCrossRefGoogle Scholar
  2. Brinkhous, K. M., Thomas, B. D., Ibrahim, S. A., and Read, M. S., 1977, Plasma levels of platelet aggregation factor/von Willebrand factor in various species, Thromb. Res. 11: 345.PubMedCrossRefGoogle Scholar
  3. Crenshaw, J. W., Jr., 1962, Variation in the serum albumin and other blood proteins of turtles of the Kinosternidae, Physiol. Zoo!. 35: 157.Google Scholar
  4. Drilhon, A., Fine, F. M., Vriel, J., and Lerourdelles, F., 1956, Analysis by immuno-electrophoresis of the constituents of serum, Comp. Rendu 243: 1802.Google Scholar
  5. Forbes, C. D., Barr, R. D., McNicol, G. P., and Douglas, A. S., 1972, Aggregation of human platelets by commercial preparations of bovine and porcine antihemophilic globulin, J. Clin. Pathol. 25: 210.PubMedCrossRefGoogle Scholar
  6. Hawiger, J., Niewiarowski, S., and Thomas, D. P., 1970, Measurement of fibrinogen and fibrin degradation products in serum by staphylococcal clumping test, J. Lab. Clin. Med. 75: 93.PubMedGoogle Scholar
  7. Homer, A. E., and Frieden, E., 1960, Changes in serum proteins during spontaneous and induced metamorphasis, J. Biol. Chem. 235: 2851.Google Scholar
  8. Irisawa, H., and Irisawa, A. F., 1954, Blood serum protein of the marine Elasmobranchii, Science 120: 849.PubMedCrossRefGoogle Scholar
  9. Lewis, J. H., and Wilson, J. H., 1973, Variations in abilities of animal fibrinogens to clump staphylococci, Thromb. Res. 3: 419.CrossRefGoogle Scholar
  10. Lipinski, B., Hawiger, J., and Jeljaszewicz, J., 1967, Staphylococcal clumping with soluble fibrin monomer complexes, J. Exp. Med. 126: 979.PubMedCrossRefGoogle Scholar
  11. Much, H., 1908, Über eine Vorstufe des Fibrinfermentes in Kulturen von Staphvlokokkus aureus, Biochem. Z. 14: 143.Google Scholar
  12. Nossel, H. L., Archer, R. K., and MacFarlane, R. G., 1962, Equine haemophilia: Report of a case and its response to multiple infusions of heterospecific AHG, Br. J. Haematol. 8: 335.PubMedCrossRefGoogle Scholar
  13. Sharp, A. A, and Bidwell, E., 1957, The toxicity and fate of injected animal antihemophilic globulin, Lancet 1: 359.CrossRefGoogle Scholar

Suggested Readings

  1. Hawiger, J., Hawiger, A., and Koenig, M. G., 1971, Staphylococcal clumping and fibrinogen and fibrin degradation products in inflammatory exudate, Proc. Soc. Exp. Biol. Med. 136: 132.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Jessica H. Lewis
    • 1
  1. 1.University of Pittsburgh School of Medicine and Central Blood BankPittsburghUSA

Personalised recommendations