Skip to main content
SpringerLink
Log in

Rodents

  • Chapter
Comparative Hemostasis in Vertebrates

Abstract

Rodentia is an extremely successful order of small, furry, gnawing animals found worldwide. Some are entirely herbivorous, others mostly insectivorous. All are characterized by high fertility and reproductive capacity. There are some endearing wild rodents, including squirrels, chipmunks, woodchucks, gophers, beavers, muskrats, and guinea pigs, and some not so well liked, such as rats, mice, and porcupines. Rats and mice cause billions of dollars worth of food and property damage and may carry various diseases such as plague and typhus. Because of their small size and high fertility rate, rats, hamsters, and guinea pigs are bred to achieve various special strains for biological research.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Lewis, J. H., 1992, Comparative hematology studies on guinea pigs (Cavia porcellus), Comp. Biochem. Physiol. 102: 507.

    Article  CAS  Google Scholar 

  • Lewis, J. H., Van Thiel, D. H., Hasiba, U., Spero, J. A., and Gavaler, J., 1985, Comparative hematology: Studies on Rodentia (rats), Comp. Biochem. Physiol. 82: 211.

    Article  CAS  Google Scholar 

Suggested Readings

  • Archambault, A., and Tremblay, J., 1965, Étude du mecanisme de la coagulation chez le cobaye. I. La thromboplastino-formation, Rev. Can. Biol. 24: 2.

    Google Scholar 

  • Archambault, A., and Tremblay, J., 1965, Étude du mecanisme de la coagulation chez le cobaye. II. La thrombino-formation et la fibrino-formation, Rev. Can. Biol. 24: 2.

    Google Scholar 

  • Archambault, A., and Tremblay, J., 1965. Study of coagulation in the guinea pig. I. Thromboplastin formation, Rev. Can. Biol. 24: 101.

    PubMed  CAS  Google Scholar 

  • Archambault, A., and Tremblay, J., 1965, Mechanism of coagulation in the guinea pig. II. Thrombin formation and fibrin formation, Rev. Can. Biol. 24: 111.

    PubMed  CAS  Google Scholar 

  • Bilbey, D. L. J., and Nicol, T., 1955, Normal blood picture of the guinea pig, Nature (London) 176: 1218.

    Article  CAS  Google Scholar 

  • Chenkin, T., and Weiner, M., 1965, A comparison of some human clotting abnormalities with the clotting pattern of normal guinea pigs, Exp. Med. Surg. 23: 398.

    PubMed  CAS  Google Scholar 

  • Constantine, J. W., 1966, Aggregation of guinea pig platelets by adenosine diphosphate, Nature (London) 210: 162.

    Article  CAS  Google Scholar 

  • Hill, B. F., 1972, The guinea pig: Management and research use, Charles River Digest, Vol. 11, p. 3, Charles River Breeding Laboratories, Wilmington, MA.

    Google Scholar 

  • Hurt, J. P., and Krigman, M., 1970, Selected procoagulants in the guinea pig, Am. J. Ph_vsiol. 218: (3): 832.

    CAS  Google Scholar 

  • Johnson, P. C., 1991, Guinea pig bleeding times, Personal communication.

    Google Scholar 

  • King, E. S., and Lucas, M., 1941, A study of the blood cells of normal guinea pigs, J. Lab. Clin. Med. 26: 1364.

    Google Scholar 

  • Latallo, Z., Niewiarowski, S., and Copley, A. L., 1958, Fibrinolytic system of guinea pig serum, Am. J. Phvsiol. 196: 779.

    Google Scholar 

  • Amin, A., and Shamloo, K. D., 1963, Distribution of the serum proteins of Syrian hamster as revealed by starch-gel electrophoresis, Nature (London) 198: 485.

    Article  CAS  Google Scholar 

  • Denyes, A., and Carter, J. D., 1961, Clotting-time of cold-exposed and hibernating hamsters, Nature (London) 190: 450.

    Article  CAS  Google Scholar 

  • Haydon, G. B., and Taylor, D. A., 1965, Microtubules in hamster platelets, J. Cell Biol. 26: 637.

    Article  Google Scholar 

  • Lyman, C. P., Weiss, L. P., O’Brien, R. C., and Barbeau, A. A., 1957, The effect of hibernation on the replacement of blood in the golden hamster, J. Exp. Zool. 136: 471.

    Article  PubMed  CAS  Google Scholar 

  • Maupin, B., 1967, Les plaquettes sanguines des mammiferes, Biol. Med. 56: 143.

    Google Scholar 

  • Ottis, K., and Tauber, O. E., 1952, Blood platelet counts of the golden hamster (Cricetus auratus), Blood 7: 948.

    PubMed  CAS  Google Scholar 

  • Stewart, M. O., Florio, L., and Mugrage, E. R., 1944, Hematological findings in the golden hamster (Cricetus auratus), J. Exp. Med. 80: 189.

    Article  PubMed  CAS  Google Scholar 

  • Svihla, A., Bowman, H., and Pearson, R., 1952, Prolongation of blood clotting time in the dormant hamster, Science 114: 272.

    Article  Google Scholar 

  • Valdivia, L. A., Lewis, J. H., Celli, S., Bontempo, F. A., Fung, J. J., Demetris, A. J., and Starzl, T. E., 1993, Hamster coagulation and serum proteins in rat recipients of hamster xenografts, Transplantation 56: 489.

    Article  PubMed  CAS  Google Scholar 

  • Behnke, O., 1967, Electron microscopic observations on the membrane systems of the rat blood platelet, Anat. Rec. 158: 121.

    Article  PubMed  CAS  Google Scholar 

  • Bums, K. F., Timmons, E. H., and Poiley, S. M., 1971, Serum chemistry and hematological values for axenic (germfree) and environmentally associated inbred rats, Lab. Anim. Sci. 21: 415.

    Google Scholar 

  • Cameron, D. G., and Watson, G. M., 1949, The blood counts of adult albino rats, Blood 4: 816.

    PubMed  CAS  Google Scholar 

  • Cotchin, E., and Roe, F. J. C., Eds., 1967, Pathology of Laboratory Rats and Mice, Blackwell, Oxford.

    Google Scholar 

  • Creskoff, A. J., Fitz-Hugh, T., Jr., and Farris, E. J., 1942, Hematology of the rat—methods and standards, in: The Rat in Laboratory Investigation, 2nd ed. ( E. J. Ferris, ed.), pp. 406–420, J. B. Lippincott, Philadelphia.

    Google Scholar 

  • DeClerck, F., Goossens, J., and Renneman, R., 1976, Effects of anti-inflammatory, anticoagulant and vasoactive compounds on tail bleeding time, whole blood coagulation time and platelet retention by glass beads in rats, Thromb. Res. 8: 179.

    Article  CAS  Google Scholar 

  • DeGabriele, G., and Penington, D. G., 1967, Physiology of the regulation of platelet production, Br. J. Haematol. 13: 202.

    Article  CAS  Google Scholar 

  • DeGaetano, G., Donati, M. B., Poggi, A., Innocenti, I. R., and Roncaglione, M. C., 1975, A peculiar haemostatic mechanism in the rat, Thromb. Res. 6: 201.

    Article  CAS  Google Scholar 

  • DeGaetano, G., Donati, M. B., Reyers-Degla, I., Innocenti, M., and Roncaglione, M. C., 1975, Defective ristocetin and bovine factor VIII–induced platelet aggregation in rats, Experientia 31: 500.

    Article  CAS  Google Scholar 

  • Dejana, E., Callioni, A., Quintana, A., and deGaetano, G., 1979, Bleeding time in laboratory animals. II. A comparison of different assay conditions in rats, Thromb. Res. 15: 191.

    Article  PubMed  CAS  Google Scholar 

  • DeLong, E., Uhley, H. N., and Friedman, M., 1959, Change in blood clotting time of rats exposed to a particular form of stress, Am. J. Physiol. 196: 429.

    CAS  Google Scholar 

  • Duvolon, S., 1947, Contribution a l’étude hematologique du rat blanc normal, Donn. Morphol. Numer. Sang 18: 205.

    CAS  Google Scholar 

  • Ebbe, S., Stohlman, F., Donovan, J., and Howard, D., 1966, Platelet survival in the rat as measured with tritium-labeled diisopropylflourophosphate, J. Lab. Clin. Med. 68: 233.

    PubMed  CAS  Google Scholar 

  • Evans, G. O., and Flynn, R. M., 1990, Further observations on in-vitro aggregation of rat platelets with different collagens, Thromb. Res. 57: 301.

    Article  PubMed  CAS  Google Scholar 

  • Farris, E. J., and Griffith, J. Q. (eds.), The Rat in Laboratory Investigation,J. B. Lippincott, Philadelphia.

    Google Scholar 

  • Gallimore, M. J., Tyler, H. M., and Shaw, J. T. B., 1971, The measurement of fibrinolysis in the rat, Thromb. Diath. Haemorrh. 26: 295.

    Google Scholar 

  • Godwin, K. O., Fraser, F. J., and Ibbotson, R. N., 1964, Haematological observations on healthy (SPF) rats, Br. J. Exp. Pathol. 45: 514.

    PubMed  CAS  Google Scholar 

  • Gogjiam, M. A., Barry, K., and Stein, B. M., 1981, Measurement of fibrinolytic activity after epsilon-aminocaproic acid administration in rats, Lab. Anim. Sci. 31: 710.

    Google Scholar 

  • Gruner, O. P. N., and Endressen, G. K. M., 1971, Platelet count and platelet stickiness in rats, Thromb. Diath. Haemmorh. 26: 389.

    CAS  Google Scholar 

  • Gunn, F. E., and Vaughan, S. L., 1930, Bone marrow reactions. II. The blood count in the albino rat: Blood platelets, Anat. Rec. 45: 59.

    Article  Google Scholar 

  • Hilgard, P., 1972, Comparative studies of the fibrinolytic system in rats and humans, Haemostasis 1: 101.

    CAS  Google Scholar 

  • Hogstorp, H., Jakobsson, H., and Carlin, G., 1981, Studies on aZ antiplasmin in the rat, Thromb. Res. 21: 247.

    Article  PubMed  CAS  Google Scholar 

  • Hohage, R., 1971, Methodical studies on platelet aggregation in the rat, Thromb. Diath. Haemorrh. 26: 393.

    PubMed  CAS  Google Scholar 

  • Kozma, C. K., Weisbroth, S. H., Stratmen, S. L., and Conejeros, M., 1969, Normal biological values for Long-Evans rats (Part II), Lab. Anim. Care 19: 746.

    PubMed  CAS  Google Scholar 

  • Li, L., and Olson, R. E., 1967, Purification and properties of rat prothrombin, J. Biol. Chem. 242: 5611.

    PubMed  CAS  Google Scholar 

  • Losonczy, G., and Harsing, L., 1982, Simultaneous activation of coagulation and fibrinolysis after severe renal ischemia in rats, Nephron 32: 180.

    Article  PubMed  CAS  Google Scholar 

  • MacGregor, L., Morazain, R., and Renaud, S., 1980, A comparison of the effect of dietary short and long chain saturated fatty acids on platelet functions, platelet phospholipids, and blood coagulation in rats, Lab. Invest. 43: 438.

    Google Scholar 

  • Mogenson, G. J., and Jaques, L. B., 1957, The effect of psychological stress procedure on the prothrombin time of rats, Blood 12: 649.

    PubMed  CAS  Google Scholar 

  • Morland, J., Holm, T., and Pyrdz, H., 1976, The influence of ethanol feeding on the activities of factors II, VII, VIII, IX, and X in rats, Thromb. Haemost. 36: 532.

    PubMed  CAS  Google Scholar 

  • Nadelhaft, I., and Lamy, F., 1972, Fibrinogen turnover in rats as a function of age, J. Lab. Clin. Med. 79: 724.

    PubMed  CAS  Google Scholar 

  • Pyorala, K., 1965, Determinants of the clotting factor response to warfarin in the rat, Ann. Med. Exp. Biol. Fenn. 43: 1.

    Google Scholar 

  • Quimby, F. H., Saxon, P. A., and Goff, L. G., 1948, Total white cell counts of peripheral and heart blood of the rat, Science 107: 447.

    Article  PubMed  CAS  Google Scholar 

  • Raymond, S. L., and Dodds, W. J., 1975, Characterization of the fawn-hooded rat as a model for hemostatic studies, Thromb. Diath. Haemorrh. 33: 361.

    PubMed  CAS  Google Scholar 

  • Reich, C., and Dunning, W. F., 1943, Studies on the morphology of the peripheral blood of rats, Cancer Res. 3: 248.

    CAS  Google Scholar 

  • Renaud, S., and Lecompte, F., 1970, Hypercoagulability induced by hyperlipemia in rat, rabbit and man, Circ. Res. 27: 1003.

    Article  PubMed  CAS  Google Scholar 

  • Renaud, S., Kuba, K., Goulet, C., Lemire, Y., and Allard, C., 1970, Relationship between fattyacid composition of platelets and platelet aggregation in rat and man, Circ. Res. 26: 553.

    Article  PubMed  CAS  Google Scholar 

  • Sinakos, Z., and Caen, J. P., 1966, Le comportement des plaquettes chez le rat, Thromb. Diath. Haemorrh. 21: 163.

    Google Scholar 

  • Soulban, G., and Labrecque, G., 1989, Circadian rhythms of blood clotting time and coagulation factors II, VII, IX and X in rats, Life Sci. 45: 2485.

    Article  PubMed  CAS  Google Scholar 

  • Surodeikina, L. N., 1965, Protein composition of blood serum of intact rats, Lab. Delo 4: 230.

    Google Scholar 

  • Suttie, J. W., 1967, Control of prothrombin and factor VII biosynthesis by vitamin K„ Arch. Biochem. Biophys. 118: 166.

    Article  CAS  Google Scholar 

  • Thwelis, E. W., and Meyer, O. O., 1942, The blood count of normal white rats, Anat. Rec. 82: 115.

    Article  Google Scholar 

  • Vainieri, H., and Wingard, L. B., 1977, Effect of warfarin on the kinetics of the vitamin K—dependent clotting factors in rats, J. Pharmacol. Exp. Ther. 201: 507.

    PubMed  CAS  Google Scholar 

  • Vondruska, J. F., and Greco, R. A., 1973, Certain hematologic and blood chemical values in Charles River CD albino rats, Bull. Am. Soc. Vet. Clin. Pathol. 22: 3.

    Google Scholar 

  • Waaler, B. A., Gustafsson, B. E., Hauge, A., Nilsson, D., and Amundsen, E., 1964, Plasma levels of various blood clotting factors in germ free rats, Proc. Soc. Exp. Biol. Med. 117: 444.

    PubMed  CAS  Google Scholar 

  • Wingard, L. B. and Levy, G., 1973, Kinetics of anti-coagulant effect of dicumarol in rats, J. Pharmacol. Exp. Ther. 184: 253.

    PubMed  CAS  Google Scholar 

  • Zoucas, E., Bergqvist, D., Goransson, G., and Bengmark, S., 1982, Effect of acute ethanol intoxication on primary haemostasis, coagulation factors and fibrinolytic activity, Eur. Surg. Res. 14: 33.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Pittsburgh School of Medicine and Central Blood Bank, Pittsburgh, Pennsylvania, USA

    Jessica H. Lewis

Authors
  1. Jessica H. Lewis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Lewis, J.H. (1996). Rodents. In: Comparative Hemostasis in Vertebrates. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9768-8_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9768-8_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9770-1

  • Online ISBN: 978-1-4757-9768-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation