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Twenty Years as a Chemist in a Positron Emission Tomography Center

  • C. Crouzel
  • B. Tavitian
  • A. M. Planas

Abstract

Positron emission tomography (PET) can be used to track molecules in the human body, and thus determine in vivo regional blood flow, blood volume, ligand-receptor interactions, sugar or lipid metabolism, and so forth. PET can also be used to explore brain function during cognitive or drug-induced stimulation, and to observe compensatory responses following damage, or during numerous diseases. PET is an interdisciplinary technic combining physics, chemistry, pharmacy, physiology, medicine, computer science and mathematics. Using some examples, we should like to illustrate the role of the chemist in a PET center and the problems he is likely to encounter.

Keywords

Positron Emission Tomography AChE Activity Positron Emission Tomography Study Positron Emission Tomography Examination Carbamate Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    A. Hammadi and C. Crouzel, 1991, Asymétrie synthesis of (2S)- and (2R)-4-(3-t-butylamino-2-hydroxypropoxy)-benzimidazol-2-[11C] one ((S) and (R)-[11C]CGP 12177) from optically active precursors. J. Lab. Compas Ratiopharm. XXIX, 6, 681–690.CrossRefGoogle Scholar
  2. 2.
    S. Bonnot-Lours, C. Crouzel, C. Prenant and F. Hinnen, 1992, Carbon-11 labelling of an inhibitor of acetylcholinesterase: [HC]physostigmine. J. Lab. Compds Ratiopharm. XXXIII, 4, 277–284.Google Scholar
  3. 3.
    C. Prenant and C. Crouzel, 1990, Synthesis of [HC]sarin. J. Lab. Compds Ratiopharm. XXVIII, 6, 645–651.CrossRefGoogle Scholar
  4. 4.
    S. Bonnot, C. Prenant and C. Crouzel, 1991, Synthesis of 9-[11C]methylamino-1,2,3,4-tetrahydroacridine, a potent acetylcholinesterase inhibitor. Appl. Radiat. Isot. 42, 7, 690–691.CrossRefGoogle Scholar
  5. 5.
    B. Tavitian, S. Pappata, A. Jobert, C. Crouzel and L. Di Giamberardino, 1993, Positron emission study of [11C]methyl-tetrahydroamino acridine (methyl-tacrine) in baboon brain. Eur. J. Pharmacol. 236, 229–239.PubMedCrossRefGoogle Scholar
  6. 6.
    B. Tavitian, S. Pappata, A.M. Planas, A. Jobert, S. Bonnot-Lours, C. Crouzel and L. Di Giamberardino, 1993, In vivo vizualisation of acetylcholinesterase with positron emission tomography. Neuro. Report 4, 5, 535–538.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • C. Crouzel
    • 1
  • B. Tavitian
    • 2
  • A. M. Planas
    • 3
  1. 1.SHFJ, DRIPP, CEAOrsayFrance
  2. 2.INSERM U33-SHFJOrsayFrance
  3. 3.CSICBarcelonaSpain

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