Fluorine-18 Labeling of Radiopharmaceuticals for PET Studies: Main Aspects and Problems Encountered in Chemical Syntheses

  • Christian Lemaire


Positron emission tomography has considerably developed during the past ten years and has proved to be the only original quantitative method appropriate to the study of the in vivo working of the brain, a field quite difficult to approach by other imaging techniques. Beside the considerable technical advances in positron tomographs, the recent progress in the radiochemistry of short-lived radionuclides have, to a large extent, contributed to the development of this functional imaging technique. Now being used in many research centers, PET studies with a labeled molecule known as radiopharmaceutical, carefully selected in respect of its biochemical properties and its in vivo biological behaviour, allow the quantitative determination of numerous physiological parameters (Phelps et al., 1986).


Radiochemical Yield Asymmetric Synthesis HPLC Purification Routine Production High Yield Synthesis 


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Christian Lemaire
    • 1
  1. 1.B-30, Cyclotron Research CenterLiège UniversityLiègeBelgium

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