Application of Fullerenes in Biomedical Imaging
The effectiveness of PET as a clinical tool can be measured by any one of several criteria, including patient care cost reductions resulting from early detection of disease and/or the avoidance of unnecessary surgery.1 As an example, clinical PET is finding widespread use in the early detection and management of coronary artery disease. Compromised myocardial blood flow(MBF) is a manifestation of coronary artery disease and can result in angina or myocardial infarctions. Several positron-emitting tracers have been utilized as blood flow agents, including ammonia labeled with the positron-emitting isotope of nitrogen, 13N, with a physical half-life(t1/2) of 9.97 minutes. Its attractiveness as a MBF agent derives from its short half-life and relative ease and low cost of production. Further, within physiological ranges, [13N]ammonia myocardial tissue concentration is linear with blood flow.2 A recently developed tracer kinetic model for quantitating blood flow has addressed some of the inherent physiological limitations encountered in the use of [13N]ammonia.3 In concert with tissue viability studies using 2-deoxy-2[18F]fluoro-D-glucose, blood flow studies with [13N]ammonia are yielding more accurate predictions regarding improved cardiac function as a result of coronary artery bypass surgery.
KeywordsMyocardial Blood Flow Proton Irradiation Porous Graphitic Carbon Flow Control Valve Incident Particle Energy
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- 1.M.E. Phelps, J.C. Mazziotta, H.R. Scheiben, R.A. Hawkins and J. Engel, Clinical PET: What are the issues? J. Nucl. Med. 26:1353(1985).Google Scholar
- 6.G. Bida, B.W. Wieland, T.J. Ruth, D.G. Schmidt, G.O. Hendry and R.E. Keen, An economical target for nitrogen-13 production by proton bombardment of a slurry of 13C powder in 16O water, J. Labelled. Compd. Radiopharm. 23:1217(1986).Google Scholar
- 10.J.-L. Morelle and E. Liénard, Can chnically useful quantities of [nitrogen-13]ammonia be produced with a 3.5 MeV deuteron beam? in: “Proceedings of the Fourth International Workshop on Targetry and Target Chemistry,” Villigen, Switzerland(1992).Google Scholar
- 12.T.J. Ruth, ed., Appendix: contributions from the accelerator manufacturers, in: “Proceedings of the Third Workshop on Targetry and Target Chemistry,” Vancouver, British Columbia (1990).Google Scholar
- 13.W.J. Gray, Reaction of graphite with water and its implications for radioactive waste storage, Radioactive Waste Manage. 1:105(1980).Google Scholar
- 14a.b) H.W. Kroto, A.W. Allaf and S.P. Balm, Fullerenes: synthesis, properties, and chemistry of large carbon clusters, in: “ACS Symposium Series No. 481,” G.S. Hammond and V.J. Kuck, eds., American Chemical Society, Washington, D.C.(1992); c) Special issue on buckminsterfullerenes, AC.E. Chem. Res. 25(1992).Google Scholar
- 16.For a review of 13N production methods up to 1980, see a) K.A. Krohn and C.A. Mathis, The use of isotopic nitrogen as a biochemical tracer, Ch. 11 and b) R.S. Tilbury, The chemical form of 13N produced in various nuclear reactions and chemical environments: A review, Ch. 13, in: “Short- Lived Radionuclides in Chemistry and Biology, Adv. Chem. Ser. No. 197,” J.W. Root and K.A.Krohn, eds., American Chemical Society, Washington, D.C.(1981).Google Scholar
- 20.M. Firouzbakht, D.J. Schlyer and A.P. Wolf, Cross-section measurements for the 13C(p,n)13N and 12C(d,n)13N nuclear reactions, J. Labelled. Compd. Radiopharm. 30:111(1991).Google Scholar
- 21.B.W. Wieland, G.T. Bida, H.C. Padgett and G.O. Hendry, Current status of CTI target systems for the production of PET radiochemicals, in: “Proceedings of the Third Workshop on Targetry and Target Chemistry,” Vancouver, British Columbia(1990).Google Scholar