Application of Fullerenes in Biomedical Imaging

  • Gerald Bida
  • Nagichettiar Satyamurthy
  • Elizabeth Zippi


The effectiveness of PET as a clinical tool can be measured by any one of several criteria, including patient care cost reductions resulting from early detection of disease and/or the avoidance of unnecessary surgery.1 As an example, clinical PET is finding widespread use in the early detection and management of coronary artery disease. Compromised myocardial blood flow(MBF) is a manifestation of coronary artery disease and can result in angina or myocardial infarctions. Several positron-emitting tracers have been utilized as blood flow agents, including ammonia labeled with the positron-emitting isotope of nitrogen, 13N, with a physical half-life(t1/2) of 9.97 minutes. Its attractiveness as a MBF agent derives from its short half-life and relative ease and low cost of production. Further, within physiological ranges, [13N]ammonia myocardial tissue concentration is linear with blood flow.2 A recently developed tracer kinetic model for quantitating blood flow has addressed some of the inherent physiological limitations encountered in the use of [13N]ammonia.3 In concert with tissue viability studies using 2-deoxy-2[18F]fluoro-D-glucose, blood flow studies with [13N]ammonia are yielding more accurate predictions regarding improved cardiac function as a result of coronary artery bypass surgery.


Myocardial Blood Flow Proton Irradiation Porous Graphitic Carbon Flow Control Valve Incident Particle Energy 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Gerald Bida
    • 1
  • Nagichettiar Satyamurthy
    • 2
  • Elizabeth Zippi
    • 3
  1. 1.Biomedical Research Foundation of Northwest LouisianaShreveportUSA
  2. 2.Department of Radiological SciencesUCLA School of MedicineLos AngelesUSA
  3. 3.National Tritium Labeling FacilityLawrence Berkeley LaboratoryBerkeleyUSA

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