Modulation by Polyunsaturated Lipid Diets of Nitrosamine-Induced Cancers in Rats: Effects on Prooxidant State and Drug Metabolism

  • Helmut Bartsch
  • Eino Hietanen
  • Markku Ahotupa
  • Anne-Marie Camus
  • Jean-Claude Béréziat


Dietary lipids are associated with increased risks for certain types of cancer, especially those of the breast and colon. This enhancing effect has been documented in humans by epidemiological studies1,2,3, as well as by studies in experimental animals4,5,6,7,8. Although the association between dietary lipids and carcinogenesis has been known for a long time, the molecular mechanism by which lipids modulate tumor development remains largely unknown.


Dietary Lipid Ethane Production Monooxygenase Activity NADPH Production Extrahepatic Tumor 


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Helmut Bartsch
    • 1
    • 2
  • Eino Hietanen
    • 1
    • 2
  • Markku Ahotupa
    • 1
    • 2
  • Anne-Marie Camus
    • 1
    • 2
  • Jean-Claude Béréziat
    • 1
    • 2
  1. 1.International Agency for Research on CancerLyon Cedex 8France
  2. 2.Department of PhysiologyUniversity of TurkuTurkuFinland (M.A.)

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