Proteolysis Associated with Thymidine-Induced Selective Cell Death in L-Cell Cultures
Previous studies in our laboratories have suggested that some established cell lines, both in vitro and in vivo, show an increased rate of proteolysis as they attain high density1–5. Unusual was the observation that this increased proteolysis appeared to be associated with a unique type of selective cell death (SCD), while the remaining viable cells continued to show a low rate of protein turnover. The exact relationship between this increased proteolysis and SCD, however, has remained elusive.
KeywordsCell Protein Protein Turnover Unbalanced Growth Vacuolar System Medium Radioactivity
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