Growth Control of Hepatocytes in Primary Culture and its Aberration in Carcinogenesis
Liver has diverse functions, and these functions are mostly carried out by mature parenchymal hepatocytes. These cells are usually quiescent in vivo, but after injury of the liver or partial hepatectomy, they grow actively, and when the original mass of liver is restored, they stop growing. Therefore, problems of central interest in hepatology are how growth of hepatocytes is initiated, how it is stopped, and how hepatocytes function during liver regeneration. These problems are important not only in cell biology, but also in hepatic surgery and carcinogenesis.
KeywordsHepatocyte Growth Factor Liver Regeneration Partial Hepatectomy Mature Hepatocyte Adult Hepatocyte
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