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Can Apoptosis Influence Initiation of Chemical Hepatocarcinogenesis?

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Chemical Carcinogenesis

Abstract

Although the mechanism of action of cell proliferation in the carcinogenic process has not been clearly defined so far, it appears that cell proliferation is essential for the initiation phase, and it also characterizes the promotion phase, as well as the progression from hepatocyte nodules to cancer1–7. Undoubtedly, most of the studies aimed to determine the exact role of cell proliferation in the development of liver cancer have been focused on the initiation step. The evidence that stems out from these studies is that at least one round of cell proliferation is necessary for the accomplishment of the initiation process; replication of DNA containing carcinogen-induced miscoding lesions such as 06-alkylguanine8, 04-alkylthymine9, or non-coding lesions such as apurinic sites10, or certain types of gap filling mechanisms11, have been implicated as the key event.

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Authors and Affiliations

  1. Istituto di Farmacologia e Patologia Biochimica, Università di Cagliari, Via Porcell, 4, 09100, Cagliari, Italy

    Amedeo Columbano, Giovanna M. Ledda-Columbano, Pierpaolo Coni, Maria G. Ennas, Dittakavi S. R. Sarma & Paolo Pani

  2. Department of Pathology, Medical Sciences Building, Toronto, M5S 1A8, Ontario, Canada

    Dittakavi S. R. Sarma

Authors
  1. Amedeo Columbano
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  2. Giovanna M. Ledda-Columbano
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  3. Pierpaolo Coni
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  4. Maria G. Ennas
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  5. Dittakavi S. R. Sarma
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  6. Paolo Pani
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Editor information

Editors and Affiliations

  1. University of Sassari, Sassari, Italy

    Francesco Feo  & Renato Garcea  & 

  2. University of Cagliari, Cagliari, Italy

    Paolo Pani  & Amedeo Columbano  & 

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© 1988 Springer Science+Business Media New York

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Columbano, A., Ledda-Columbano, G.M., Coni, P., Ennas, M.G., Sarma, D.S.R., Pani, P. (1988). Can Apoptosis Influence Initiation of Chemical Hepatocarcinogenesis?. In: Feo, F., Pani, P., Columbano, A., Garcea, R. (eds) Chemical Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9640-7_33

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  • DOI: https://doi.org/10.1007/978-1-4757-9640-7_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9642-1

  • Online ISBN: 978-1-4757-9640-7

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