Interaction of Activated N-Nitrosamines with DNA
Some chemically induced tumors in rodents are associated with single point mutations in ras genes1. It is important to know whether these mutations arise at sites in DNA of unusually high reactivity for ultimate carcinogens, or whether carcinogen interaction is random. This information is not available for simple methylating agents such as those derived from N-nitroso compounds.
KeywordsSingle Point Mutation Plasmid pBR322 Methylating Agent Methyl Phosphate Apurinic Site
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- 2.M. C. Archer and G. E. Labuc, Nitrosamines, in: “Bioactivation of Foreign Compounds”, M. W. Anders, ed., Academic Press, New York, NY, USA (1985).Google Scholar
- 14.R. C. Shank and P. N. Magee, Toxicity and carcinogenicity of N-nitroso compounds, in: “Mycotoxins and N-nitroso Compounds: Environmental Risks”, R.C. Shank, ed., CRC press, Boca Raton, FL, USA (1981).Google Scholar