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Design and Development of Enzymatic Organic Synthesis

  • C.-H. Wong
Part of the Industry-University Cooperative Chemistry Program Symposia book series (IUCC)

Abstract

The rate acceleration and selectivity of various enzymatic reactions operated under mild conditions are the major attractive features of enzymes for use as catalysts in organic synthesis. Many natural and unnatural enzymatic reactions have been demonstrated for multigram scale synthesis of chiral organic molecules1. The number of enzymes isolated (about 2,500), however, only represents approximately 2% of the total number of enzymes which may exist in nature. So far, there have been only about 50 enzymes exploited for use in organic synthesis. With an increasing number of enzymes available, the synthetic methods based on enzyme catalysis are being extended from the preparation of small chiral molecules to the synthesis of more complex molecules such as oligosaccharides, polypeptides, nucleotides and their conjugates. This review describes the most recent developments in my laboratory in this area with emphasis on the synthesis of carbohydrates and polypeptides.

Keywords

Aldol Reaction Dihydroxyacetone Phosphate Amidase Activity Diethyl Acetal Amide Hydrolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • C.-H. Wong
    • 1
  1. 1.Department of ChemistryResearch Institute of Scripps ClinicLa JollaUSA

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