Matrix Metalloproteinases in Experimental Autoimmune Encephalomyelitis
The matrix metalloproteinases (MMPs) belong to a large subgroup of Zn2+-dependent neutral endoproteinases, which includes the collagenases, gelatinases, and the stromelysins. The number of MMPs known is growing rapidly and they all share at least four common features : (a) they all display proteolytic activity, (b) they are functionally active in the extracellular space, and on the eDNA level (c) protein sequences for the cysteine switch mechanism (PRCGxPD), which is important for their activation, and (d) protein sequences for the binding of catalytic zinc (HExGHxxGxxHS/T) can be found.
KeywordsMultiple Sclerosis Experimental Autoimmune Encephalomyelitis Proteolytic Activity Myelin Basic Protein Neuroinflammatory Disease
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