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Selective Proteolytical Cleavage of the Ligand-Binding Chains of the IL-2-Receptor and IL-6-Receptor by Neutrophil-Derived Proteases

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Cellular Peptidases in Immune Functions and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 421))

Abstract

Soluble forms of usually membrane bound molecules were identified in blood or other body fluids. Among these soluble forms of membrane proteins, which have been found to lack the transmembrane and the intracellular domain, the soluble cytokine receptors are of interest, because they have been found to be capable of binding the ligand and of influencing the biological activity of the cytokines1,2.

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Authors and Affiliations

  1. Institute of Experimental Internal Medicine, Center of Internal Medicine, Leipziger Str. 44, D-39120, Magdeburg, Germany

    U. Bank, D. Reinhold & S. Ansorge

  2. Institute of Clinical Chemistry, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, D-39120, Magdeburg, Germany

    D. Kunz

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  1. U. Bank
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  2. D. Reinhold
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  3. D. Kunz
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  4. S. Ansorge
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Editors and Affiliations

  1. Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany

    Siegfried Ansorge

  2. Institute of Medical Immunology, Martin Luther University, Halle, Germany

    Jürgen Langner

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Bank, U., Reinhold, D., Kunz, D., Ansorge, S. (1997). Selective Proteolytical Cleavage of the Ligand-Binding Chains of the IL-2-Receptor and IL-6-Receptor by Neutrophil-Derived Proteases. In: Ansorge, S., Langner, J. (eds) Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology, vol 421. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9613-1_30

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  • DOI: https://doi.org/10.1007/978-1-4757-9613-1_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9615-5

  • Online ISBN: 978-1-4757-9613-1

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