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Aminopeptidase N-Mediated Signal Transduction and Inhibition of Proliferation of Human Myeloid Cells

  • M. Löhn
  • C. Mueller
  • K. Thiele
  • T. Kähne
  • D. Riemann
  • J. Langner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 421)

Abstract

Cell surface peptidases are involved in degradative processes of various peptides, in cell-cell communcation, in lymphocyte activation and in cell growth1,2,3,4. Aminopeptidase N (APN, CD 13), a ubiquitously occurring surface molecule of many tissues, among them human liver, kidneys, intestine, placenta, bone marrow or brain microvessels, acts with a relatively broad substrate specifity on peptides with N-terminal neutral amino acids 5. Within the haematopoietic system CD13 is localized on monocytes, granulocytes and activated T lymphocytes5,6,7,8.

Keywords

U937 Cell Bath Solution Chelate Zinc Human Myeloid Cell Cell Surface Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • M. Löhn
    • 1
  • C. Mueller
    • 1
  • K. Thiele
    • 1
  • T. Kähne
    • 2
  • D. Riemann
    • 1
  • J. Langner
    • 1
  1. 1.Institute of Medical ImmunologyMartin Luther University Halle/SaaleHalle/SaaleGermany
  2. 2.Institute of Experimental Internal MedicineOtto von Guericke UniversityMagdeburgGermany

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