Long-Term Potentiation of Synaptic Transmission in the Hippocampus Obeys Hebb’s Rule for Synaptic Modification
Cellular mechanisms for associative memory are generally assumed to involve synaptic changes dependent on a conjunction between activity in different neuronal elements, and various principles for such conjunctive control of synaptic modification have been proposed (Brindley, 1969; von Baumgarten, 1970). In the model for neuronal memory put forward by Hebb (1949), the strengthening of synaptic connections was postulated to occur as a result of nearly simultaneous firing of the pre- and the postsynaptic cells. Long-term potentiation (LTP) in the hippocampus is a synaptic strengthening process that has been implicated in learning and memory (Bliss and L¢mo, 1973; Teyler and Discenna, 1984), and recent studies have suggested that its induction is controlled by coincident pre- and postsynaptic activity in general agreement with Hebb’s rule for synaptic modification (Wigström et al., 1986; Kelso et al., 1986).
KeywordsCurrent Pulse Cell Firing Postsynaptic Cell Synaptic Modification Postsynaptic Spike
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