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Modulation of the Gaba- and Pentobarbital-Gated Cl Current by Intracellular Calcium in Frog Sensory Neurons

  • Tooru Maruyama
  • Yutaka Oomura
  • Junichi Sadoshima
  • Naofumi Tokutomi
  • Jan Behrends
  • Norio Akaike

Abstract

Voltage-dependent Ca2+ currents are well known to play an important role in the regulation of a vast number of neuronal functions. The transient increase in intracellular free calcium resulting from Ca2+-channel activation has been shown to trigger various ionic currents in the soma of a variety of nerve cells, i.e., calcium-dependent potassium, chloride, or unselective anion conductances. In addition to this well-established interaction with ionic channels, Ca2+ has been demonstrated to modulate desensitization kinetics of ACh receptors in the neuromuscular end plate (Miledi, 1980) and to inhibit a nicotinic chloride response in Aplysia neurons (Chemeris et al., 1982) as well as the nicotinic cation response in frog sympathetic ganglion cells (Morita et al., 1979). These findings point to a possible involvement of Ca2+ ions not only in the regulation of pure ionic channels but also in the modulation of transmitter-operated receptor—ionophore complexes.

Keywords

Gaba Receptor External Solution Intracellular Free Calcium Rapid Application Gaba Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Tooru Maruyama
    • 1
  • Yutaka Oomura
    • 1
    • 2
  • Junichi Sadoshima
    • 1
  • Naofumi Tokutomi
    • 1
  • Jan Behrends
    • 1
  • Norio Akaike
    • 1
  1. 1.Department of Physiology, Faculty of MedicineKyushu UniversityFukuoka 812Japan
  2. 2.Department of Biological Control SystemsNational Institute for Physiological SciencesOkazaki 444Japan

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