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Long-Term Effects of Firing on Excitability of Hippocampal CA1 Neurons

  • S. Pockett
  • O. C. J. Lippold

Abstract

Backfiring a hippocampal CA 1 cell by stimulation of its axon can, under certain circumstances, cause it to become less excitable to synaptic input (Dunwiddie and Lynch, 1978). We have investigated the basis of this lowered excitability.

Keywords

Vertical Arrow Tungsten Wire Test Pulse Population Spike Population Spike Amplitude 
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References

  1. Andersen P., Eccles, J. C., and Løyning, Y., 1964, Pathway of postsynaptic inhibition in the hippocampus, J. Physiol. (Lond.) 27: 608–619.Google Scholar
  2. Dunwiddie, T., and Lynch, G., 1978, Long-term potentiation and depression of synaptic responses in the rat hippocampus: Localization and frequency dependency, J. Physiol. (Lond.) 276: 353–367.Google Scholar
  3. Halliwell, J. V., and Adams, P. R., 1982, Voltage-clamp analysis of muscarinic excitation in hippocampal neurons, Brain Res. 250: 71–92.PubMedCrossRefGoogle Scholar
  4. Zbicz, K. L., and Weight, F. F., 1985, Transient voltage and calcium-dependent outward currents in hippocampal CA3 pyramidal neurons, J. Neurophysiol. 53: 1038–1058.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • S. Pockett
    • 1
  • O. C. J. Lippold
    • 2
  1. 1.Department of PhysiologyUniversity of AucklandAucklandNew Zealand
  2. 2.Department of Human PhysiologyRoyal Holloway and Bedford New CollegeEghamEngland

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