The Role of Neuronal Activity in the Long-Term Regulation of Synaptic Performance at the Crayfish Neuromuscular Junction
Long-term changes in synapses produced by altered impulse activity may be an important mechanism underlying forms of learning. The long-term effects of impulse activity on the physiology and morphology of well-defined synapses can be studied at the neuromuscular junction (Robbins, 1980). This is particularly true for crustacean neuromuscular synapses, where muscles are innervated by relatively few motoneurons. In crustacean muscles the activity of identified motoneurons can be monitored and selectively altered for extended periods in vivo. Identified neuromuscular synapses can be examined physiologically and morphologically. In addition, many of the physiological and morphological features of crustacean neuromuscular synapses are similar to synapses in the central nervous system (Atwood, 1982).
KeywordsFatigue Depression Immobilization Acetylcholine Gelatin
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