Postsynaptic Events Associated with Long-Lasting Activity-Induced Changes in Excitability of Neocortical Neurons
It is well established that changes in excitability of neocortical neurons that persist, undiminished, for tens of minutes can be induced by increasing the firing rate for just a few minutes. Any of a number of experimental procedures can be used to increase firing, including depolarizing current, synaptic activation, and iontophoresis of glutamate or acetylcholine (Burns, 1957; Bindman et al., 1964; Bindman and Boisacq-Schepens, 1966; McCabe, 1973; Woody et al., 1978). The site of the underlying change has been localized to the neocortex in experiments carried out a neuronally isolated slabs of cortex in vivo (Bliss et al., 1968). Both increases and decreases in excitability of different neurons were observed following stimulation in a number of these studies.
KeywordsInput Resistance Membrane Capacity Interspike Interval Spike Amplitude Neocortical Neuron
Unable to display preview. Download preview PDF.
- Bindman, L. J., and Boisacq-Schepens, N., 1966, Persistent changes in the rate of firing of single, spontaneously active cortical cells in the rat produced by peripheral stimulation, J. Physiol. (Lond.) 185: 14–17 P.Google Scholar
- Bindman, L. J., Lippold, O. C. J., and Redfeam, J. W. T., 1964, The action of brief polarizing currents on the cerebral cortex of the rat, (1) during current flow, and (2) in the production of long-lasting aftereffects, J. Physiol. (Loud.) 172: 369–382.Google Scholar
- Bindman, L. J., Lippold, O. C. J., and Milne, A. R., 1979, Prolonged changes in excitability of pryamidal tract neurons in the cat, J. Physiol. (Lond.) 286: 457–477.Google Scholar
- Birdman, L. J., Meyer, T., and Pockett, S., 1987, Long-term potentiation in rat neocortical neurones in slices, produced by repetitive pairing of an afferent volley with intracellular depolarizing current, J. Physiol. (Lond.) 386: 90 P.Google Scholar
- Bindman, L. J., Meyer, T., and Prince, C. A., 1985, Intracellular measurements of the electrical properties of neurones in the cerebral cortex of the rat: Comparative data from slices in vitro and from the anaesthetized animal, J. Physiol. (Lond.) 341: 7–8 P.Google Scholar
- Bliss, T. V. P., and Lomo, T., 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path, J. Physiol. (Lond.) 232: 331–356.Google Scholar
- Bliss, T. V. P., Bums, B. D., and Uttley, A. M., 1968, Factors affecting the conductivity of pathways in the cerebral cortex, J. Physiol. (Lond.) 195: 339–367.Google Scholar
- Bums, B. D., 1957, Electrophysiologic basis of normal and psychotic function, in: Psychotropic Drugs ( S. Garattini and V. Ghetti, eds.), Elsevier, Amsterdam, pp. 177–184.Google Scholar
- Frankenheuser, B., 1957, The effect of calcium on the myelinated nerve fibre, J. Physiol. (Lond.) 137: 245–260.Google Scholar
- Lev-Tov, A., and Rahamimoff, R., 1980, A study of tetanic and post-tetanic potentiation of miniature endplate potentials at the frog neuromuscular junction, J. Physiol. (Lond.) 309: 247–273.Google Scholar
- McCabe, B. J., 1973, Production of Prolonged Changes in Cortical Neuronal Activity by lontophoresis of L-Glutamate in Anaesthetized and Unanaesthetized Rats, Ph.D. thesis, University of London.Google Scholar
- Wigström, H., and Gustafsson, B., 1986, Postsynaptic control of hippocampal long-term potentiation, J. Physiol. (Paris) 81: 228–236.Google Scholar