The Cellular Basis for Short-Term Memory in Endocrine Systems
A common property of many endocrine systems is an anamnestic response. For instance, when pancreatic islets are reexposed to a standard glucose stimulus after a prior period of exposure to the same glucose challenge, their insulin secretory response is greater to the second than to the first stimulus (Gold et al., 1982; Grill et al., 1978, 1979; Grill and Rundfeldt, 1979; Grill, 1981; Grodsky et al., 1969). A similar pattern is seen on repeated exposure of adrenal glomerulosa cells to the peptide hormone angiotensin II. Recent work in both of these systems indicates that protein kinase C plays a central role in mediating the sustained phase of each of these endocrine responses (Kojima et al., 1984; Tanigawa et al., 1982; Zawalich et al., 1983, 1984). Work in our laboratories over the past 18 months has focused on the possible role of protein kinase C in this type of short-term cellular memory in bovine adrenal glomerulosa cells and isolated rat pancreatic islets.
KeywordsInsulin Secretion Phosphatidic Acid None None Influx Rate Insulin Secretory Response
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