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The Nuclear Lamina

An Intermediate Filament Protein Structure of the Cell Nucleus
  • George N. Dessev

Abstract

During interphase, eukaryotic cells are physically separated into a nuclear and a cytoplasmic compartment by a complex organelle, the nuclear envelope. The innermost layer of the nuclear envelope is a polymeric protein network (Fawcett, 1966; Fawcett, 1981) termed the nuclear lamina (NL) (Fig. 1), which is tightly associated with the nuclear pore complexes. Apposed to the cytoplasmic surface of the NL is the membrane component of the nuclear envelope, which consists of two lipid bilayers, containing intrinsic membrane proteins. It is likely that the NL is a ubiquitous feature found in all eukaryotic cells, although it is not always equally prominent by electron microscopy.

Keywords

Nuclear Envelope Intermediate Filament Nuclear Membrane Xenopus Laevis Nuclear Pore Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • George N. Dessev
    • 1
  1. 1.Department of Cell, Molecular, and Structural BiologyNorthwestern University Medical SchoolChicagoUSA

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