Skip to main content
SpringerLink
Log in
Book cover

Cell Fusion pp 331–352Cite as

Physicochemical Factors Underlying Lipid Membrane Fusion

  • Chapter

Abstract

Membrane fusion is one of the essential events involved in many biological cellular processes (Poste and Allison, 1973; Rasmussen, 1970). In spite of extensive research on membrane fusion, its molecular mechanism is not well understood. This is probably due to the many possible molecular pathways for various membrane fusion events and also because of the complex nature of biological membranes (Poste and Nicolson, 1978).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Blum, L., and Jancovici, B., 1984, Exactly soluble model for the interaction of two parallel charged plates in an ionic medium, J. Phys. Chem.88:2294–2297.

    Article  CAS  Google Scholar 

  • Breisblatt, W., and Ohki, S., 1975, Fusion in phospholipid spherical membrane. I. Effect of temperature and lysolecithin, J. Membrane Biol.23:385–401.

    Article  CAS  Google Scholar 

  • Chaudhury, M., and Ohki, S., 1981, Correlation between membrane expansion and temperature-induced membrane fusion, Biochim. Biophys. Acta 642:365–374.

    Article  PubMed  CAS  Google Scholar 

  • Chung, L., Kaloyanides, G., McDaniel, R., McLaughlin, A., and McLaughlin, S., 1985, Interaction of gentamicin and spermine with bilayer membrane containing negatively charged phospholipids, Biochemistry 24:442–452.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, F. S., Zimmerberg, J., and Finkelstein, A., 1980, Fusion of phospholipid vesicles with planar phospholipid bilayer membranes. II. Incorporation of a vesicular membrane marker into the planar membrane, J. Gen. Physiol 75:251–270.

    Article  PubMed  CAS  Google Scholar 

  • Davies, J. T., and Rideal, E. K., 1961, Interfacial Phenomena, Academic Press, New York.

    Google Scholar 

  • Düzgünes, N., and Ohki, S., 1977, Calcium-induced interaction of phospholipid vesicles and bilayer lipid membranes, Biochim. Biophys. Acta 467:301–308.

    Article  PubMed  Google Scholar 

  • Hammoudah, M. M., Nir, S., Isac, T., Kornhauser, R., Stewart, T. P., Hui, S. W., and Vaz, W. L. C., 1979, Interaction of La3+ with phosphatidylserine vesicle: Binding, phase transition, leakage and fusion, Biochim. Biophys. Acta 558:338–343.

    Article  PubMed  CAS  Google Scholar 

  • Herrman, A., Pratsch, L., Arnold, K., and Lassman, G., 1983, Effect of poly(ethylene glycol) on the polarity of aqueous solutions and on the structure of vesicle membranes, Biochim. Biophys. Acta 733:87–94.

    Article  Google Scholar 

  • Hiemenz, P. C., 1977, Principles of Colloid and Surface ChemistrY., Marcel Dekker, New York.

    Google Scholar 

  • Hong, K., Schuber, F., and Papahadjopoulos, D., 1983, Biological modulators of membrane fusion, Biochim. Biophys. Acta 732:469–472.

    Article  PubMed  CAS  Google Scholar 

  • Hui, S. W., Stewart, T. P., Boni, L. T., and Yeagle, P. L., 1981, Membrane fusion through point defects in bilayers, Science 212:921–923.

    Article  PubMed  CAS  Google Scholar 

  • Knutton, S., 1979, Studies of membrane fusion. III. Fusion of erythrocytes with polyethylene glycol, J. Cell Sci.36:61–72.

    PubMed  CAS  Google Scholar 

  • LeNeveu, D. M., Rand, R. P., and Parsegian, V. A., 1976, Measurement of forces between lecithin bilayers, Nature (Lond.) 259:601–603.

    Article  CAS  Google Scholar 

  • London, F., 1937, The general theory of molecular forces, Trans. Faraday Soc.33:8.

    Article  CAS  Google Scholar 

  • Lucy, J. A., 1970, The fusion of biological membranes, Nature (Lond.) 227:814–817.

    Article  Google Scholar 

  • Miller, C., Arvan, P., Telford, J. N., and Racker, E., 1976, Ca2+-induced fusion of proteoliposomes: Dependence on transmembrane osmotic gradient, J. Membrane Biol. 30:271–282.

    Article  CAS  Google Scholar 

  • Ohki, S., and Fukuda, N., 1968, Interaction energy between water and hydrocarbon phases, J. Colloid Interface Sci.27:208–215.

    Article  CAS  Google Scholar 

  • Ohki, S., 1977, The oil-water interface, a model membrane system, in: The Fifty-First Colloid and Surface Science Symposium, pp. 134–135, Grand Island, New York.

    Google Scholar 

  • Ohki, S., 1982, A mechanism of divalent ion-induced phosphatidylserine membrane fusion, Biochim. Biophys. Acta 689:1–11.

    Article  PubMed  CAS  Google Scholar 

  • Ohki, S., 1984, Effects of divalent cations, temperature, osmotic pressure gradient, and vesicle curvature on phosphatidylserine vesicle fusion, J. Membrane Biol.77:265–275.

    Article  CAS  Google Scholar 

  • Ohki, S., and Ohshima, H., 1984, Divalent cation-induced surface tension increase in acidic phospholipid membranes: ion binding and membrane fusion, Biochim. Biophys. Acta 776:177–182.

    Article  CAS  Google Scholar 

  • Ohki, S., and Duax, J., 1986, Interaction of polyamines with phosphatidylserine membranes, Biochim. Biophys. Acta 861:177–186.

    PubMed  CAS  Google Scholar 

  • Ohki, S., Düzgünes, N., and Leonards, K., 1982, Phospholipid vesicle aggregation: Effect on monovalent and divalent ions, Biochemistry 21:2127–2133.

    Article  PubMed  CAS  Google Scholar 

  • Ohshima, H., and Ohki, S., 1985, Effects of divalent cations on the surface tension of a lipid monolayer-coated air/water interface, J. Colloid Interface Sci.102:85–94.

    Article  Google Scholar 

  • Pashley, R. M., McGuigganm, P. M., Ninhan, B. W., and Evans, D. F., 1985, Attractive forces between uncharged hydrophobic surfaces: Direct measurements in aqueous solution, Science 299:1085–1089.

    Google Scholar 

  • Papahadjopoulos, D., Vail, W. J., Newton, C., Nir, S., Jacobson, K., Poste, G., and Lazo, R., 1977, Studies on membrane fusion. III. The role of calcium-induced phase changes, Biochim. Biophys. Acta 465:579–598.

    Article  PubMed  CAS  Google Scholar 

  • Poste, G., and Allison, A. C., 1973, Membrane fusion, Biochim. Biophys. Acta 300:421–465.

    Article  PubMed  CAS  Google Scholar 

  • Poste, G., and Nicolson, G. L., eds., 1978, Membrane Fusion, Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • Rand, P., 1981, Interacting phospholipid bilayers: Measured forces and induced structural charges, Rev. Biophys. Bioeng.10:277–314.

    Article  CAS  Google Scholar 

  • Rasmussen, H., 1970, Cell communication, calcium ion, and cyclic adenosine monophosphate, Science 170:404–412.

    Article  PubMed  CAS  Google Scholar 

  • Rouser, G., Bauman, A J., Kritchevsky, G., Heller, D., and O’Brien, J. S., 1961, Quantitative chromatographic fractionation of complex lipid mixtures: Brain lipids, J. Am. Oil Chem. Soc.38:544–555.

    Article  CAS  Google Scholar 

  • Schuber, F., Hong, K., Düzgünes, N., and Papahadjopoulos, D., 1983, Polyamines as modulators of membrane fusion: Aggregation and fusion of liposomes, Biochemistry 22:6134–6140.

    Article  PubMed  CAS  Google Scholar 

  • Schullery, S. E., Schmidt, C. F., Felgner, P., Tillack, T. W., and Thompson, T. E., 1980, Fusion of dipalmitoyl-phosphatidylcholine vesicles, Biochemistry 19:3919–3923.

    Article  PubMed  CAS  Google Scholar 

  • van Oss, C. J., Good, R. J., and Chaudhury, M. K., 1986, J. Colloid Interface Sci. (in press).

    Google Scholar 

  • Verkleij, A. J., Van Echteld, C. J. A., Gerritsen, W. J., Cullis, P. R., and DeKruijff, B., 1980, The lipidic particle as an intermediate structure in membrane fusion processes and bilayer to hexagonal HII transitions, Biochim. Biophys. Acta 600:620–624.

    Article  PubMed  CAS  Google Scholar 

  • Verwey, E. J. W., and Overbeek, J. Th. G., 1948, Theory of the Stability of Lyophobic Colloids, Elsevier, Amsterdam.

    Google Scholar 

  • Vincent, B., 1973, The van der Waals attraction between colloid particles having adsorbed layers. II. Calculation of interaction curves, J. Colloid Interface Sci.42:270–285.

    Article  CAS  Google Scholar 

  • Vold, M. J., 1961, The effect of adsorption on the van der Waals interaction of spherical colloidal particles, J. Colloid Sci.16:1–12.

    Article  CAS  Google Scholar 

  • Weast, R. C., ed., 1965, Handbook of Chemistry and Physics, The Chemical Rubber Co., Cleveland, Ohio.

    Google Scholar 

  • Wilschut, J., and Papahadjopoulos, D., 1979, Ca2+-induced fusion of phospholipid vesicles monitored by mixing of aqueous contents, Nature (Lond.) 281:690–692.

    Article  CAS  Google Scholar 

  • Wilschut, J., Düzgünes, N., and Papahadjopoulos, D., 1980, Studies on the mechanism of membrane fusion: Kinetics of Ca ion induced fusion of phosphatidylserine vesicles followed by a new assay for mixing of aqueous vesicle contents, Biochemistry 19:6011–6021.

    Article  PubMed  CAS  Google Scholar 

  • Wilschut, J., Düzgünes, N., and Papahadjopoulos, D., 1981, Calcium/magnesium specificity in membrane fusion: Kinetics of aggregation and fusion of phosphatidylserine vesicles and the role of bilayer curvature, Biochemistry 20:3126–3133.

    Article  PubMed  CAS  Google Scholar 

  • Zimmermann, U., 1982, Electric field-mediated fusion and related electrical phenomena, Biochim. Biophys. Acta 694:227–277.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biophysical Sciences, School of Medicine, State University of New York at Buffalo, Buffalo, New York, 14214, USA

    Shinpei Ohki

Authors
  1. Shinpei Ohki
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. American National Red Cross, Rockville, Maryland, USA

    Arthur E. Sowers

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ohki, S. (1987). Physicochemical Factors Underlying Lipid Membrane Fusion. In: Sowers, A.E. (eds) Cell Fusion. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9598-1_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9598-1_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9600-1

  • Online ISBN: 978-1-4757-9598-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation