Lactones are often obtained by carbonylation reactions closely related to the acyclic ester syntheses described in the previous chapter. Although only limited data are available for carbonylative routes to four- and six-membered lactone rings, the preparation of five-membered (γ) lactones has been one of the most intensively studied areas of carbonylation chemistry in recent years. Palladium catalysis in particular has provided a number of extremely clean and facile syntheses, including routes to a wide range of α-methylene-γ-lactones.
KeywordsCobalt Catalyst Styrene Oxide Oxidative Carbonylation Allylic Alcohol Propargylic Alcohol
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