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Synthesis of Carboxylic Acids

  • H. M. Colquhoun
  • D. J. Thompson
  • M. V. Twigg

Abstract

From the standpoint of carbonylation chemistry, carboxylic acids and their derived esters, amides, anhydrides, and acyl halides are best regarded as a group of closely related and readily interconvertible compounds based on the formally disconnected structure {[E] +...CO...[Nu]}. In most cases [E] represents a potentially electrophilic carbon-centered fragment (alkyl, vinyl, aryl, etc.), but can also be a hydrogen- or a heteroatom-centered group such as [RO] (in carbonate derivatives) or [R2N] (in carbamates). The group [Nu] is represented by one of the more or less nucleophilic species [HO], [RO], [R2N], [RCOO], or [X] (where X = halogen).

Keywords

Carboxylic Acid Acetyl Iodide Benzyl Halide Carbonylation Chemistry Arylacetic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • H. M. Colquhoun
    • 1
  • D. J. Thompson
    • 2
  • M. V. Twigg
    • 3
  1. 1.ICI Chemicals and Polymers Ltd.RuncornEngland
  2. 2.ICI Specialty ChemicalsWilmingtonUSA
  3. 3.European Vinyls Corporation InternationalBrusselsBelgium

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