This chapter is concerned with the practical aspects of carbonylation chemistry. In view of the very active catalyst systems now available, autoclave equipment is only occasionally required and there is rarely any need for the extremes of pressure and temperature synonymous with older industrial carbonylation processes. Small-scale atmospheric pressure procedures can in fact often be carried out in conventional laboratory glassware. In procedural terms, carbonylation reactions can be most closely compared with hydrogenations, both types of reaction involving gas handling and transition metal catalysis. Although carbon monoxide requires particularly careful handling in view of its toxicity and the potentially explosive nature of its mixtures with air, when used correctly it is a versatile reagent that can be employed safely in most laboratories.
KeywordsCarbon Monoxide Needle Valve Metal Carbonyl Carbonylation Reaction Threshold Limit Value
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