Synthesis of Lactams and Related N-Heterocycles
In view of the widespread occurrence of lactam rings, particularly the β-lactam ring, in pharmacologically active compounds such as the penicillins and cephalosporins, intensive efforts have been made in recent years to develop carbonylation-based methodologies for constructing this type of subunit.(449) This work has led to the discovery of a number of routes to β-, γ-, and δ-lactams, the more useful of which are outlined in the present chapter.
KeywordsCarbonylation Palladium Aniline Rhodium Imide
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