Carbonylation pp 191-203 | Cite as

Synthesis of Lactams and Related N-Heterocycles

  • H. M. Colquhoun
  • D. J. Thompson
  • M. V. Twigg


In view of the widespread occurrence of lactam rings, particularly the β-lactam ring, in pharmacologically active compounds such as the penicillins and cephalosporins, intensive efforts have been made in recent years to develop carbonylation-based methodologies for constructing this type of subunit.(449) This work has led to the discovery of a number of routes to β-, γ-, and δ-lactams, the more useful of which are outlined in the present chapter.


Metal Carbonyl Palladium Acetate Benzyl Isoquinolines Lactam Ring Cobalt Carbonyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • H. M. Colquhoun
    • 1
  • D. J. Thompson
    • 2
  • M. V. Twigg
    • 3
  1. 1.ICI Chemicals and Polymers Ltd.RuncornEngland
  2. 2.ICI Specialty ChemicalsWilmingtonUSA
  3. 3.European Vinyls Corporation InternationalBrusselsBelgium

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