Carbonylation pp 191-203 | Cite as

Synthesis of Lactams and Related N-Heterocycles

  • H. M. Colquhoun
  • D. J. Thompson
  • M. V. Twigg

Abstract

In view of the widespread occurrence of lactam rings, particularly the β-lactam ring, in pharmacologically active compounds such as the penicillins and cephalosporins, intensive efforts have been made in recent years to develop carbonylation-based methodologies for constructing this type of subunit.(449) This work has led to the discovery of a number of routes to β-, γ-, and δ-lactams, the more useful of which are outlined in the present chapter.

Keywords

Carbonylation Palladium Aniline Rhodium Imide 

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • H. M. Colquhoun
    • 1
  • D. J. Thompson
    • 2
  • M. V. Twigg
    • 3
  1. 1.ICI Chemicals and Polymers Ltd.RuncornEngland
  2. 2.ICI Specialty ChemicalsWilmingtonUSA
  3. 3.European Vinyls Corporation InternationalBrusselsBelgium

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