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A Basic Concept for PET-BNCT System

  • Y. Imahori
  • S. Ueda
  • Y. Ohmori
  • E. Yoshino
  • K. Ono
  • T. Kobayashi
  • T. Ido
  • Y. Mishima

Abstract

[10B]Boronophenylalanine (10B-BPA) has been used as a tumor selective boron carrier for boron neutron capture therapy (BNCT) in the treatment of malignant melanoma1. In the same way, it is thought to be a potential boron carrier for the treatment of malignant glioma2–4. Glioma infiltrates peripheral brain tissue and we always fall into the dilemma between resection and preservation of the infiltrated brain. Thus the treatment will be effective in these infiltrative tumors. In our studies of malignant glioma using positron emission tomography (PET), accumulation of 10B-BPA analog, [18F]fluoroboronophenylalanine (18F-10B-FBPA), in tumor lesion was dramatically revealed3. The metabolic analysis of this positron-emitting analog demonstrated that enhancement of the amino acid transport is a primary factor for the high accumulation3,5. [18F]Fluoroboronophenylalanine has been recognized as a compound that is incorporated into tumor cell selectively.

Keywords

Positron Emission Tomography Positron Emission Tomography Study Positron Emission Tomography Data Boron Neutron Capture Therapy Incorporation Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Y. Imahori
    • 1
  • S. Ueda
    • 1
  • Y. Ohmori
    • 1
  • E. Yoshino
    • 1
  • K. Ono
    • 2
  • T. Kobayashi
    • 2
  • T. Ido
    • 3
  • Y. Mishima
    • 4
  1. 1.Department of Neurosurg.Kyoto Prefectural University of Med.Kyoto 602Japan
  2. 2.Kyoto University Research Reactor InstituteOsaka 590Japan
  3. 3.Cyclotron and RI CenterTohoku UniversitySendai 980Japan
  4. 4.Mishima Institute for Derm. ResearchKobe 650Japan

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