Uptake and Biological Effects of the Carborane Based Boron Compounds DAC-1 and DAAC-1
The amount of boron needed for successful treatment of tumour cells has been calculated to be about 109 10B-atoms when the boron is in the cytoplasm or 108 10B-atoms when located in the cell nucleus.1,2 An amount of 108 10B-atoms in the cell nucleus gives a boron dependent dose of about 2 Gy high-LET irradiation if a reasonable thermal neutron fluence (about 5×1012 n/cm2) is applied2 and this gives most likely a valuable therapeutic effect. An amount of 108 10B-atoms per cell corresponds to an average 10B concentration in the cells of about 1.5–2.0 ppm (μg boron/g tissue) if the cell diameter is about 10 μm. If the average cellular concentration is significantly above 10 ppm, then there is a good chance to inactivate cell division by boron dependent captures.
KeywordsGlioma Cell Colon Carcinoma Malignant Glioma Boron Concentration Boron Content
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