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Chemical Modeling with p-Boronophenylalanine for Boron Accumulation to and Release from Melanoma

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Book cover Cancer Neutron Capture Therapy

Abstract

This paper describes a proposed mechanism of boron accumulation to and release from melanoma after administration of p-Boronophenylalanine (p-BPA) to melanoma patients. The study is based on chemical experiments modeling the phenomena occurring in melanoma cells. Before the mechanism study, we would like to mention the history of the BNCT compound, p-BPA.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Shinshu University, Asahi Matsumoto 390, Japan

    Kazuo Yoshino, Yoshihiro Mori & Hiroaki Takahashi

  2. Energy Research Center Wakasa Bay, Tsuruga 914, Japan

    Hidetake Kakihana

  3. Mishima Skin Clinic, Mishima Institute for Dermatological Research, Kobe 657, Japan

    Yutaka Mishima

  4. Kobe University School of Medicine, Kobe 650, Japan

    Masamitsu Ichihashi

Authors
  1. Kazuo Yoshino
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  2. Yoshihiro Mori
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  3. Hidetake Kakihana
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  4. Hiroaki Takahashi
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  5. Yutaka Mishima
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  6. Masamitsu Ichihashi
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Editor information

Editors and Affiliations

  1. Mishima Institute for Dermatological Research, Kobe, Japan

    Yutaka Mishima (President) (President)

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© 1996 Springer Science+Business Media New York

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Yoshino, K., Mori, Y., Kakihana, H., Takahashi, H., Mishima, Y., Ichihashi, M. (1996). Chemical Modeling with p-Boronophenylalanine for Boron Accumulation to and Release from Melanoma. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_9

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  • DOI: https://doi.org/10.1007/978-1-4757-9567-7_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9569-1

  • Online ISBN: 978-1-4757-9567-7

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