Acute Toxicity of Elaidyl-1,2,-Carborane Carboxylate (ECC) in Rats
An effective boronation of low density lipoprotein (LDL), a potential boron carrier for BNCT, has been achieved with the elaidyl ester of 1,2,-carborane carboxylate (ECC)1,2. It is likely that in the body ECC will be cleaved into the carborane moiety and elaidyl alcohol. The elaidyl alcohol part will be changed back to elaidic acid, the trans form of oleic acid, and handled like trans fatty acids in general. The other part of ECC, 1,2-closo carborane, is a stable ortho carborane (OC)3 as the carboxylic acid. OC is quite nontoxic, peroral LD50 for mice is 9g/kg4. The toxicity of ECC is not known.
KeywordsTrans Fatty Acid Injection Well Boron Concentration Elaidic Acid National Engineer Laboratory
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