Assessment of Radiation Induced Damage of Mouse Brain Using 18F-2-Deoxy-D-Glucose and 99mTc-Hexamethylpropylene Amine Oxine
The most severe radiation-induced brain damage is brain necrosis. Clinically, it is difficult to differentiate between brain necrosis and recurrent brain tumor1. Radiation brain necrosis is a terminal stage of the brain damage. However, it is not well known the mechanisms underlying the process that produce the brain necrosis after irradiation: i.e. how glucose metabolism and blood flow distribution change after irradiation. We studied the uptake of 18F-2-deoxy-D-glucose (FDG) and 99mTc-hexamethylpropylene amine oxine (HMPAO) in the irradiated brain of the mouse regarding glucose and blood flow distribution, respectively. This study is a feasible for positron emission tomography.
KeywordsPositron Emission Tomography Uptake Ratio Brain Damage Blood Flow Distribution Recurrent Brain
Unable to display preview. Download preview PDF.
- 1.G. Di Chiro et al. Cerebral necrosis after radiation therapy and/or intraarterial chemotherapy for brain tumors: PET and neurologic studies. AJNR 8: 1083–1091, 1987.Google Scholar