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Evaluation of Response to Thermal Neutron Irradiation in Quiescent Cell Populations Within Murine Solid Tumors Using Micronucleus Assay

  • Shin-ichiro Masunaga
  • Koji Ono
  • Tooru Kobayashi
  • Keizo Akuta
  • Mitsuhiko Akaboshi
  • Masao Takagaki
  • Mitsuyuki Abe
  • Peter C. Keng

Abstract

Boron neutron capture therapy has a potential to become the ideal cancer therapy, which selectively and maximally damages malignant cells with sparing normal tissue. This modality selectively concentrates a boron compound in malignant cells, and then activates this compound with slow thermal neutrons resulting in a lethal event within the cancer cell1,2. On the other hand, it is well known that many tumor cells are not proliferating (quiescent) in situ, but are still chronogenic. To improve treatment against cancer, it is also necessary to determine the response of quiescent tumor cells to the treatment.

Keywords

Thermal Neutron Quiescent Cell Boron Neutron Capture Therapy Relative Biological Effectiveness Binucleate Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    R.V. Dorn III. Boron neutron capture therapy (BNCT): a radiation oncology perspective. Int J Radiai Oncol Biol Phys. 28: 1189–1201, 1994.CrossRefGoogle Scholar
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    R.F. Barth, A.H. Soloway, R.G. Fairchild, and R.M. Brugger. Boron neutron capture therapy for cancer. Cancer. 70: 2995–3007, 1992.PubMedCrossRefGoogle Scholar
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    K. Ono, E. Wandl, K. Tsutsui, K. Sasai, and M. Abe. The correlation between cell survival curve and dose-response curve of micronucleus (MN) frequency. Strahlenther Onkol. 165: 824–827, 1989.PubMedGoogle Scholar
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    S. Masunaga, K. Ono, and M. Abe. A method for the selective measurement of the radiosensitivity of quiescent cells in solid tumors-combination of immunofluorescence staining to BrdU and micronucleus assay. Radiat Res. 125: 243–247, 1991.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Shin-ichiro Masunaga
    • 1
  • Koji Ono
    • 1
  • Tooru Kobayashi
    • 1
  • Keizo Akuta
    • 2
  • Mitsuhiko Akaboshi
    • 1
  • Masao Takagaki
    • 1
  • Mitsuyuki Abe
    • 3
  • Peter C. Keng
    • 4
  1. 1.Research Reactor InstituteKyoto UniversityKumatori-cho, Sennan-gun OsakaJapan
  2. 2.Department of RadiologyOtsu Red Cross HospitalShiga 520Japan
  3. 3.Department of Radiology Faculty of MedicineKyoto UniversityKyotoJapan
  4. 4.Tumor Biology Division Cancer CenterUniversity of RochesterRochesterUSA

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