Effectiveness of Borocaptate Sodium for Boron Neutron Capture Therapy in Malignant Brain Tumors
Since 1990, we have treated fourteen glioblastoma patients by BNCT using BSH according to Hatanaka’s procedures. However, in our early patients, who were almost all advanced cases, good clinical results were not obtained, probably because the tumor to blood ratio of 10B concentration in our BNCT subjects was always under 1 and/or around lOppm, respectively, considerably lower than the expected values. In our recent subjects, assuming the T/B ratio to be 1.0, the 10B concentration in blood was maintained at around 30ppm during BNCT to achieve a 10B concentration in the tumor of 28ppm, the theoretically required minimum concentration. This strategy improved the post-BNCT course in glioblastoma patients. In both glioblastoma patients and brain tumor animals models, the T/B ratio of BSH has been reported to show wide variations (l, 2, 3). To estimate the optimal dosage of BSH, we have previously investigated the quantitative distribution of BSH in tumors and blood in newly diagnosed subjects and in brain tumor-bearing animals. In this study, we investigated the quantitative distribution of BSH via prompt gamma ray spectroscopy (PGS) and an α-track etch method (ATM) in newly diagnosed human glioblastoma patients and its effectiveness was discussed for the clinical purpose.
KeywordsTumor Vessel Malignant Brain Tumor Boron Neutron Capture Therapy Glioblastoma Patient Track Density
Unable to display preview. Download preview PDF.
- 1.H. Hatanaka., K. Amano., H. Kanemitsu., I. Ikeuchi. and T. Yoshizaki.: Boron uptake by human brain tumors and quality control of boron compounds. In Boron-Neutron Capture Therapy (Eds. Hatanaka, H.), Nishimura Co. Ltd., Japan, 77–106, 1986.Google Scholar
- 2.G. C. Finkel, C. E. Poletti, R. G. Fairchild, D.N. Slatkinand and W. H. Sweet.: Distribution of “’B after Infusion ofNa,i°Bi,HiiSH into a Patient with Malignant Astrocytoma: Implications for Boron Neutron Capture Therapy. Neurosurgery, 24 (1), 6–1 I, 1989.Google Scholar
- 3.D. Haritz, K. Piscol and D. Gabel.: The distribution of BSH in patients with malignant glioma. in the Progress in Neutron Capture Therapy for Cancer (Eds. B. J. Allen et al.), Plenum Press. New York p.p. 557–560, 1992.Google Scholar
- 4.S. L. Kraft, P.R. Gavin, C. E. Dehaan, C. W. Leathers, W. F. Bauer, D. L. Miller and R. V. Dorn III.: Borocaptate sodium: A potential boron delivery compound for boron neutron capture therapy evaluated in dogs with spontaneous intracranial tumors. Proc. Natl. Acad. Sci. USA, 89, pp. 11973-I 1977, 1992.Google Scholar
- 5.K. Kitao.: Vascular wall dose from boron neutron capture reaction. In Boron-Neutron Capture Therapy for Tumors (Ed. Hatanaka, H.), Nishimura Co., Ltd., pp 191–202, 1986.Google Scholar