Enhanced Tumor Uptake of Boronophenylalanine by Means of Osmotic Blood-Brain Barrier Disruption in Glioma—Bearing Rats
The endothelial cells of capillaries within the brain constitute a barrier for the delivery of water-soluble drugs to this anatomic site. Intracarotid infusions of hyperosmotic solutions of mannitol disrupt these tight endothelial cell junctions both in normal brain and intracerebral tumors1. Neuwelt et al. have shown that osmotic blood-brain barrier (BBB) disruption can increase the uptake of both low and high molecular weight substances by brain tumors in experimental animals and humans2,3. The purpose of the present study was to determine if BBB disruption could significantly and specifically enhance the uptake of p-boronophenylalanine (BPA), which has been used as a capture agent for boron neutron capture therapy (BNCT) of intracerebral gliomas and melanomas in experimental animal studies4,5. The following report describes our studies on the effects of BBB disruption on the uptake of BPA using the F98 rat glioma, which simulates human glioblastoma multiforme in its biologic behavior.
KeywordsToxicity Catheter Albumin Agarose Boron
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