T1 Measurement to Study the Penetration of BNCT Agents Into Canine Tumors Caused by Blood Brain Barrier Damage
The blood brain barrier (BBB), maintained primarily by cerebral capillary endothelial cells, protects the brain by limiting the uptake and circulation of drugs1. It has been observed that the BBB is disrupted during brain tumor growth. The fenestrated capillaries allow large molecules, such as protein and blood products, to penetrate through the BBB and be taken up by tumors cells2. As a consequence, certain boron agents for Boron Neutron Capture Therapy (BNCT), such as borocaptate sodium (BSH)3, are able to penetrate the disrupted BBB and enter tumor tissues. The study of BBB disruption by tumor growth will assist in understanding the mechanism of this penetration and provide a background for BSH pharmacokinetics.
KeywordsNormal Brain Tissue Blood Brain Barrier Permeability Spin Echo Boron Neutron Capture Therapy Blood Brain Barrier Disruption
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