Advertisement

T1 Measurement to Study the Penetration of BNCT Agents Into Canine Tumors Caused by Blood Brain Barrier Damage

  • Peng-Peng P. Zhu Tang
  • Martin P. Schweizer
  • J. Rock Hadley
  • Shonn P. Hendee
  • Richard H. Tippets
  • Kenneth M. Bradshaw

Abstract

The blood brain barrier (BBB), maintained primarily by cerebral capillary endothelial cells, protects the brain by limiting the uptake and circulation of drugs1. It has been observed that the BBB is disrupted during brain tumor growth. The fenestrated capillaries allow large molecules, such as protein and blood products, to penetrate through the BBB and be taken up by tumors cells2. As a consequence, certain boron agents for Boron Neutron Capture Therapy (BNCT), such as borocaptate sodium (BSH)3, are able to penetrate the disrupted BBB and enter tumor tissues. The study of BBB disruption by tumor growth will assist in understanding the mechanism of this penetration and provide a background for BSH pharmacokinetics.

Keywords

Normal Brain Tissue Blood Brain Barrier Permeability Spin Echo Boron Neutron Capture Therapy Blood Brain Barrier Disruption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bradbury MWB, The concept of a blood-brain barrier. Wiley, Chichester, 1979.Google Scholar
  2. 2.
    Long DM, Capillary ultrastructure and the blood-brain barrier in human malignant brain tumors. J neuosur. 32: 127–144, 1970.CrossRefGoogle Scholar
  3. 3.
    Soloway AH, Hatanaka H, and Davis MA, Penetration of brain and brain tumor, VII: Tumor-binding sulfhydryl boron compounds. J. Med. Chem. 10: 714–717, 1967.PubMedCrossRefGoogle Scholar
  4. 4.
    Weinmann HJ, Brasch RC, Press WR, and Wesbey GE, Characteristics of gadolinium-DTPA complex: A potential NMR contrast agent. AJR, 142: 619–624, 1984.PubMedCrossRefGoogle Scholar
  5. 5.
    Brasch RC, Weinmann HJ, Press WR, and Wesbey GE, Contrast-enhanced NMR imaging: Animal studies using gadolinium-DTPA complex. AJR, 142: 625–630, 1984.PubMedCrossRefGoogle Scholar
  6. 6.
    Norman AB, Bertram KJ, Thomas SR, Pratt RG, Samaratunga RC, and Sanberg PR, Magnetic resonance imaging of rat brain following in vivo disruption of the cerebral vasculature. Brain Res. Bull. 26 (4): 593–597, 1991.PubMedCrossRefGoogle Scholar
  7. 7.
    Tofts PS, and Kermode AG, Measurement of the blood-brain-barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Mag. Reson. Med. 17: 357–367, 1991CrossRefGoogle Scholar
  8. 8.
    Kenney J, Schmiedl U, Maravilla K, Starr F, Graham M, Spence A, and Nelson J, Measurement of blood-brain-barrier permeability in a tumor model using magnetic resonance imaging with gadoliniumDTPA. Mag. Reson. Med. 27: 68–75. 1992.CrossRefGoogle Scholar
  9. 9.
    Schmiedl UP, Kenney J, and Maravilla KR, Kinetics of pathologic blood-brain-harrier permeability in an astrocytic glioma using contrast-enhanced MR. AJNR, 13: 5–14, 1992.PubMedGoogle Scholar
  10. 10.
    Larsson HBW, Stubgaard M, Frederiksen JL, Jensen M, Henriksen O, and Paulson OB. Quantization of blood-brain-barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors. Mag. Reson. Med. 16: 117–131, 1990.CrossRefGoogle Scholar
  11. 11.
    Wang HZ, Riederer SJ, and Lee JN, Optimizing the precision in T1 relaxation estimation using limited flip angles. Mag Reson. Med. 5: 399–46, 1987.CrossRefGoogle Scholar
  12. 12.
    Fram EK, Herfkens RJ, Johnson GA, Glover GH, Karis JP, Shimakawa A, Perkins TG, and Pelc NJ, Rapid calculation of T 1 using variable flip angle gradient refocused imaging. J. Mag. Reson. Image. 5: 201–8. 1987.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Peng-Peng P. Zhu Tang
    • 1
  • Martin P. Schweizer
    • 1
    • 2
    • 4
  • J. Rock Hadley
    • 1
    • 5
  • Shonn P. Hendee
    • 1
    • 4
  • Richard H. Tippets
    • 3
  • Kenneth M. Bradshaw
    • 1
    • 5
  1. 1.Department of RadiologyUniversity of UtahSalt Lake CityUSA
  2. 2.Department of Medicinal ChemistryUniversity of UtahSalt Lake CityUSA
  3. 3.Department of NeurosurgeryUniversity of UtahSalt Lake CityUSA
  4. 4.Department of BioengineeringUniversity of UtahSalt Lake CityUSA
  5. 5.Neutron TechnologyBoiseUSA

Personalised recommendations