A Microdosimetry Model for In Vitro Boron Neutron Capture Irradiation Experiments Using d(14)+Be-Neutrons
It was shown that radiation effects in tumor cells treated with fast neutrons may be increased by neutron capture reactions 10B(n, α)7Li. Monte Carlo calculations of the energy depositions of short range particles with high LET coming from 10B disintegrations were performed and compared to the observed biological effects. The simulation allows us to study the influence of the localization of 10B localized inside the cell.
Calculations for a human melanoma cell population treated as monolayer in the presence or absence of boron with d(14)+Be-neutrons will be demonstrated. Two different 10B-enriched boron compounds were investigated in this study: boric acid (H3 10BO3) and p-dihydroxyboryl phenylalanine (BPA). The computer simulations indicate that BPA yield a higher potential effectiveness for inactivation of melanoma cells than boric acid.
KeywordsBoric Acid Fast Neutron Neutron Capture Boron Neutron Capture Therapy Boron Compound
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