A Microdosimetry Model for BNCT Analysis

  • Corine Vroegindeweij
  • Floyd J. Wheeler
  • Finn Stecher-Rasmussen
  • René Huiskamp
  • Detlef Gabel

Abstract

The therapeutic effect of boron neutron capture therapy depends on the microscopic distribution of the boron atoms. A given macroscopic boron distribution can yield completely different therapeutic effects for different distributions of the boron atoms on a microscopic scale. In this work, a stochastic model for the subcellular dosimetry has been developed to calculate the effect of BNCT in tumour cells as well as in capillaries for different capture reactions and for proton recoil. The microdosimetry model calculates the dose distribution on a cellular scale, the probability functions of energy depositions in the cell nucleus (hit size curve) and the cell survival fractions.

Keywords

Boron Haas Rene 

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References

  1. 1.
    P.R. Gavin, R. Huiskamp, F.J. Wheeler and M.L. Griebenow, Computer modelling the boron compound factor in normal brain tissue, in: “Advances in Neutron Capture Therapy”, A.H. Soloway et al. ed., Plenum Press, New York, 1993, pp 591–595.CrossRefGoogle Scholar
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    F. Stecher-Rasmussen, G. Constantine, W. Freudenreich, H.J.M. de Haas, R.L. Moss, A. Paardekoper, K. Ravensberg, H. Verhagen, W. Voorbraak and P.R.D. Watkins, From filter installation to beam characterization, in: “Boron Neutron Capture Therapy”, D. Gabel and R. Moss ed., Plenum Press, New York, 1992, pp 59–77.CrossRefGoogle Scholar
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    F.J. Wheeler, private communication.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Corine Vroegindeweij
    • 1
  • Floyd J. Wheeler
    • 2
  • Finn Stecher-Rasmussen
    • 1
  • René Huiskamp
    • 1
  • Detlef Gabel
    • 3
  1. 1.Netherlands Energy Research FoundationECNPettenThe Netherlands
  2. 2.Idaho National Engineering LaboratoryINELIdaho FallsUSA
  3. 3.Department of ChemistryUniversity of BremenGermany

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