Determination of Boron Dose for BNCT Using Fricke and EPR Dosimetry
In Boron Neutron Capture Therapy (BNCT), the dominant dose delivered to the tumor is due to α- and 7 Li-charged particles resulting from neutron capture by 10B and is referred to as the boron dose. Boron dose is directly attributable to its concentration and also to the neutron energy spectrum because the neutron capture cress-section in boron has an 1/v dependence. The distribution of neutron energy at a given point is dictated by the incident neutron-energy distribution, the depth in tissue, and geometrical factors such as the beam’s size and patient’s dimensions. These factors can be accounted for using Monte Carlo simulations1. However, when using conventional dosimetry for BNCT, e.g., TLDs or ionization chambers, boron dose can only be estimated. Many of the issues on BNCT dosimetry were addressed in Ref. 2.
KeywordsElectron Paramagnetic Resonance Boric Acid Electron Paramagnetic Resonance Spectrum Neutron Capture Boron Neutron Capture Therapy
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- 2.Zamenhof R.G., Solares G.R., and Harling O.K., Eds., Topics in Dosimetry & Treatment Planning for Neutron Capture Therapy. Advanced Medical Publishing, Madison, Wisconsin. (1994).Google Scholar
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