Boron-Rich Oligophosphates — Novel Molecules for Use in BNCT
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For some time we1,2 and others3,4 have been interested in the use of immunoproteins for the selective localization of boron-10 in tumors. A significant challenge inherent in this approach is the requirement that each immunoprotein must be conjugated to (or otherwise associated with) approximately 103 boron-10 atoms in order to attain the necessary tumor concentrations of boron-10. Early work suggested that the development of methods for the facile synthesis of macromolecules containing large numbers of boron atoms, which we call ‘trailer’ molecules, would be necessary for the successful application of this approach to BNCT.5,6 Our research in this area has been focused upon the design of boron-rich trailers that are simple and economical to synthesize, water soluble, and homogeneous.
KeywordsBoron Atom Boron Neutron Capture Therapy Anionic Phosphate Automate Synthesis Tumor Concentration
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