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Boron-, Gadolinium-Porphyrin Derivatives for Neutron Capture Therapy

MRI and ICP Study
  • Akira Matsumura
  • Yasushi Shibata
  • Kunio Nakagawa
  • Tetsuya Yamamoto
  • Takashi Yoshizawa
  • Yoshihiko Yoshii
  • Tadao Nose
  • Isao Sakata
  • Susumu Nakajima
  • Naoto Miwa

Abstract

New porphyrin derivatives conjugated with boron(B) or gadolinium(Gd) were developed to use as compound for neutron capture therapy in order to obtain tumor selective accumulation of B or Gd. In neutron capture therapy, it is essential to know the B or Gd distribution in the tumor and in the normal brain. Using sodium borocaptate (BSH), detection of the boron concentration in the tumor and blood before the therapy require operative sampling and additional analysis such as inductively coupled plasma (ICP) analysis (1) and still the intratumoral heterogeneity of B distribution can not be analyzed precisely. Our study was aimed to develop B or Gd compounds for neutron capture therapy which could be visualized on MRI. This compound enables preoperative evaluation of the spatial distribution of B or Gd and its clearance from the tissue without operative samplings. Such porphyrin derivatives are thought to be useful in neutron capture therapy.

Keywords

Inductively Couple Plasma Atomic Emission Spectroscopy Boron Concentration Inductively Couple Plasma Atomic Emission Spectroscopy Boron Neutron Capture Therapy Porphyrin Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Akira Matsumura
    • 1
  • Yasushi Shibata
    • 1
  • Kunio Nakagawa
    • 1
  • Tetsuya Yamamoto
    • 1
  • Takashi Yoshizawa
    • 1
  • Yoshihiko Yoshii
    • 1
  • Tadao Nose
    • 1
  • Isao Sakata
    • 2
  • Susumu Nakajima
    • 3
  • Naoto Miwa
    • 4
  1. 1.Department of Neurosurgery Institute of Clinical MedicineUniversity of TsukubaIbaraki, 305Japan
  2. 2.Toyo Hakka Co. Ltd.Japan
  3. 3.Department of Operative SurgeryAsahikawa Medical CollegeJapan
  4. 4.Research InstituteNihon Schering Co. Ltd.Japan

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