Boron-, Gadolinium-Porphyrin Derivatives for Neutron Capture Therapy
New porphyrin derivatives conjugated with boron(B) or gadolinium(Gd) were developed to use as compound for neutron capture therapy in order to obtain tumor selective accumulation of B or Gd. In neutron capture therapy, it is essential to know the B or Gd distribution in the tumor and in the normal brain. Using sodium borocaptate (BSH), detection of the boron concentration in the tumor and blood before the therapy require operative sampling and additional analysis such as inductively coupled plasma (ICP) analysis (1) and still the intratumoral heterogeneity of B distribution can not be analyzed precisely. Our study was aimed to develop B or Gd compounds for neutron capture therapy which could be visualized on MRI. This compound enables preoperative evaluation of the spatial distribution of B or Gd and its clearance from the tissue without operative samplings. Such porphyrin derivatives are thought to be useful in neutron capture therapy.
KeywordsInductively Couple Plasma Atomic Emission Spectroscopy Boron Concentration Inductively Couple Plasma Atomic Emission Spectroscopy Boron Neutron Capture Therapy Porphyrin Derivative
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