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Determination of Mn-BOPP Concentrations Using Neutron Activation Analysis and MRI

  • Matthew J. Combs
  • Robert U. Mulder
  • Stuart S. Berr
  • Carmen Oveissi
  • Stephen B. Kahl

Abstract

Many investigators are experimenting with new BNCT compounds in an attempt to introduce more boron in cancer cells. Accurate determination of boron levels in tissues and blood is rather tedious, requiring specialized equipment to perform prompt γ-ray analysis, inductively coupled plasma atomic emission spectroscopy or boron MRI1. Although these methods are sensitive with detection levels near or below 1 ppm boron, none of the facilities required for those techniques are available at the University of Virginia and similarly, at many other universities. Under such circumstances, alternative methods of analysis would be useful.

Keywords

Neutron Activation Analysis Boron Concentration Couple Plasma Atomic Emission Spectroscopy Minimum Detectable Activity Boron Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    D.E. Moore, A review of the techniques for the analysis of boron in the development of neutron capture therapy agents. J. Pharm & Biom. Analysis, 8: 547–553, 1990.CrossRefGoogle Scholar
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    L.R. Huang, R.M. Straubinger, S.B. Kahl, M.S. Koo, J.J. Alletto, R. Mazurchuck,R.I. Chau, S.L. Thamer, R. J. Fiel, Boronated Metalloporphyrins: A novel approach to the diagnosis and treatment of cancer using contrast-enhanced MR imaging and neutron cancer therapy. JMRI 3: 351–356, 1993.PubMedCrossRefGoogle Scholar
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    G.F. Knoll. “Radiation Detection and Measurement,” Wiley & Sons, New York, 1989, pp. 703–710.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Matthew J. Combs
    • 1
    • 2
  • Robert U. Mulder
    • 1
  • Stuart S. Berr
    • 2
  • Carmen Oveissi
    • 1
  • Stephen B. Kahl
    • 3
  1. 1.Department of Mechanical, Aerospace and Nuclear EngineeringUniversity of VirginiaCharlottesvilleUSA
  2. 2.Department of RadiologyUniversity of Virginia Health Sciences CenterCharlottesvilleUSA
  3. 3.Department of PharmacyUniversity of California San FranciscoSan FranciscoUSA

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