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Spatial and Temporal Distribution of Boron Uptake in Excised Samples of Human Rheumatoid Synovium

  • L. S. Johnson
  • J. C. Yanch
  • S. Shortkroff
  • C. B. Sledge

Abstract

Use of the 10B(n,α)7Li nuclear reaction to treat rheumatoid arthritis is currently under investigation at MIT1. This paper will describe experimental studies which demonstrate that very large concentrations of 10B are readily taken up by joint tissues, in vitro. Boron concentrations 5 – 25 times larger than those typically observed in BNCT research are easily obtained. The requirements for further experimental work are described. Also discussed are the potential advantages of treating rheumatoid arthritis via the neutron capture reaction, including the requirement for substantially smaller neutron flux and the correspondingly smaller healthy tissue dose.

Keywords

Rheumatoid Arthritis Boric Acid Neutron Capture Boron Neutron Capture Therapy Boric Acid Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • L. S. Johnson
    • 1
  • J. C. Yanch
    • 1
  • S. Shortkroff
    • 2
  • C. B. Sledge
    • 2
  1. 1.Nuclear Engineering DepartmentWhitaker College of Health Sciences and Technology Massachusetts Institute of TechnologyCambridgeUSA
  2. 2.Department of Orthopedic SurgeryBrigham and Women’s HospitalBostonUSA

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