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New Small Molecular Weight Agents for Boron Neutron Capture Therapy

  • A. H. Soloway
  • I. M. Wyzlic
  • W. Tjarks
  • J. A. Hariharan
  • M. Burgos-Fuster
  • R. F. Barth

Abstract

The development of new BNCT agents requires a priori that the compounds that are synthesized possess the capability of distinguishing between tumor, contiguous normal tissues and other tissues in the path of the neutron beam. This must be achieved not in trace amounts but in levels of the order of 20–50 micrograms of B-10 per gram of tumor or approximately 109 boron atoms per cell1. The question which has plagued the synthetic chemists involved is how can this be accomplished? Information derived from cancer chemotherapy has not been helpful per se since the basis for success or failure of such agents has been strictly a biological and not a concentration endpoint. In the case of radiopharmaceuticals used as cancer diagnostic agents, the chemical amounts are at such trace levels that one cannot extrapolate from this information to estimate what would be the concentration and tissue differentials expected where significant amounts of material are administrated as required for BNCT.

Keywords

Neutron Beam Boron Atom Boron Neutron Capture Therapy SiMe3 SiMe3 Polyamine Analog 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • A. H. Soloway
    • 1
  • I. M. Wyzlic
    • 1
  • W. Tjarks
    • 1
  • J. A. Hariharan
    • 1
  • M. Burgos-Fuster
    • 1
  • R. F. Barth
    • 1
  1. 1.The Ohio State UniversityColumbusUSA

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