Abstract
Many pharmacokinetic experiments were carried out with tumor-bearing animals and patients using p-Boronophenylalanine(p-BPA)-fructose complex, and the selective boron accumulation property in the tumors was confirmed.1,2 As the results, p-BPA fructose complex has been used for Boron Neutron Capture Therapy (BNCT) of malignant melanoma and brain tumors.3,4 But, mechanism studies about the accumulation properties are few.5 Recently, we have proposed a chemical model representing boron accumulation in and its release from melanoma.6 This mechanism is based on the facts that p-BPA is complexed by Dopa, which is greatly produced in melanoma cells, that the complex is then decomposed by tyrosinase to form boric acid. Although the above-mentioned chemical reactions had been rally observed in test tubes, it was still ambiguous whether these reactions do occur or not in a human body. The present paper deals with this point. One of the methods of confirming the phenomena in vivo is 11B-NMR. Since the signal width of boric acid is sharp compared with that of p-BPA and the chemical shift of boric acid is different from that of p-BPA, we can examine whether the decomposition occurs. But, the application of 11B-NMR to the human tissue is not so easy. Improvement of the sample tube and of the NMR module are required.
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© 1996 Springer Science+Business Media New York
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Yoshino, K. et al. (1996). Examination of Stability of p-, m-, o-Boronophenylalanine in Blood with High Performance Liquid Chromatography. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_14
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DOI: https://doi.org/10.1007/978-1-4757-9567-7_14
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