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New Unnatural Boron-Containing Amino Acids and Peptides as Potential Delivery Agents for Neutron Capture Therapy

  • Iwona M. Wyzlic
  • John C. Beeson
  • Albert H. Soloway
  • Jinghong Yong
  • Rolf F. Barth

Abstract

Since Boron Neutron Capture Therapy is to be used in the treatment of primary and metastatic brain tumors, it is essential that the boron compounds be capable of crossing the blood-brain barrier (BBB) prior to their incorporation into tumor cells. It has been shown1 that derivatives of L-phenylalanine are transported across the BBB by neutral amino acid transport system. Recently, a method has been developed to deliver low molecular weight peptides into brain.2 These observations suggest that boronated analogues of phenylalanine itself and their peptides modified by replacing aromatic amino acids with highly lipophilic, carborane-containing amino acids might be used to reach and become incorporated into brain tumor cells protected by BBB.

Keywords

Aromatic Amino Acid Boron Neutron Capture Therapy Metastatic Brain Tumor Benzyl Ester Brain Tumor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Iwona M. Wyzlic
    • 1
  • John C. Beeson
    • 1
  • Albert H. Soloway
    • 1
  • Jinghong Yong
    • 1
  • Rolf F. Barth
    • 1
  1. 1.The Ohio State UniversityColumbusUSA

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