Boron Neutron Capture Therapy of Spontaneous Intracranial Tumors in Dogs
Normal tissue tolerance studies have been extended to 23 dogs with spontaneously occurring tumors. All animals were treated with a single 10×10 cm dorsal portal following the infusion of borocaptate sodium. Blood-boron concentrations at the time of radiation have varied between 20 and 100 μg/g. Objective tumor response was seen in some animals. Radiation brain necrosis was seen in 3 dogs. The bimodal therapy presents a complex challenge in attempting to achieve dose response assays. The results indicate a large dose-sparing effect from the boron capture reactions within the blood.
KeywordsLinear Energy Transfer Radiation Necrosis Boron Neutron Capture Therapy Compute Tomogra Choroid Plexus Papilloma
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