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Boron Neutron Capture Therapy of Spontaneous Intracranial Tumors in Dogs

BSH and Epithermal Neutrons
  • P. R. Gavin
  • S. L. Kraft
  • C. D. Swartz
  • C. E. Dehaan
  • F. J. Wheeler
  • W. M. Bauer

Abstract

Normal tissue tolerance studies have been extended to 23 dogs with spontaneously occurring tumors. All animals were treated with a single 10×10 cm dorsal portal following the infusion of borocaptate sodium. Blood-boron concentrations at the time of radiation have varied between 20 and 100 μg/g. Objective tumor response was seen in some animals. Radiation brain necrosis was seen in 3 dogs. The bimodal therapy presents a complex challenge in attempting to achieve dose response assays. The results indicate a large dose-sparing effect from the boron capture reactions within the blood.

Keywords

Linear Energy Transfer Radiation Necrosis Boron Neutron Capture Therapy Compute Tomogra Choroid Plexus Papilloma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • P. R. Gavin
    • 1
  • S. L. Kraft
    • 2
  • C. D. Swartz
    • 1
  • C. E. Dehaan
    • 3
  • F. J. Wheeler
    • 4
  • W. M. Bauer
    • 4
  1. 1.Department of Veterinary Clinical SciencesWashington State UniversityPullman, WashingtonUSA
  2. 2.Department of RadiologyKansas State UniversityManhattanUSA
  3. 3.PetalumaUSA
  4. 4.Idaho National Engineering LabEG&G Idaho, Inc.Idaho FallsUSA

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