Abstract
Normal tissue tolerance studies have been extended to 23 dogs with spontaneously occurring tumors. All animals were treated with a single 10×10 cm dorsal portal following the infusion of borocaptate sodium. Blood-boron concentrations at the time of radiation have varied between 20 and 100 μg/g. Objective tumor response was seen in some animals. Radiation brain necrosis was seen in 3 dogs. The bimodal therapy presents a complex challenge in attempting to achieve dose response assays. The results indicate a large dose-sparing effect from the boron capture reactions within the blood.
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Gavin, P.R., Kraft, S.L., Swartz, C.D., Dehaan, C.E., Wheeler, F.J., Bauer, W.M. (1996). Boron Neutron Capture Therapy of Spontaneous Intracranial Tumors in Dogs. In: Mishima, Y. (eds) Cancer Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9567-7_108
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